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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1868
Target Type SINGLE PROTEIN
Preferred Name Vascular endothelial growth factor receptor 1
Synonyms FLT | FLT | FLT-1 | FLT1 | FRT | Fms-like tyrosine kinase 1 | Tyrosine-protein kinase FRT | Tyrosine-protein kinase receptor FLT | VEGFR-1 | VEGFR1 | Vascular endothelial growth factor receptor 1 | Vascular permeability factor receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase vegfr family

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor receptor 1 SINGLE PROTEIN P17948

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095227 Vascular endothelial growth factor receptor PROTEIN FAMILY
CHEMBL2111480 Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102755
Ensembl ENSG00000102755
GO Cellular Component GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005794 (Golgi apparatus)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005021 (vascular endothelial growth factor receptor activity)
GO:0005524 (ATP binding)
GO:0019838 (growth factor binding)
GO Biological Process GO:0007565 (female pregnancy)
GO:0030154 (cell differentiation)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
Wikipedia FLT1

Target Cross References - Protein

canSAR P17948
Human Protein Atlas ENSG00000102755
PharmGKB PA28180
Reactome REACT_12529 (Signaling by VEGF.)
UniProt A8KA71 B0LPF1 B3FR89 B5A923 O60722 P16057 P17948 Q12954

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001824 (Tyr_prot_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR009134 (Tyr_prot_kinase_VEGFR_rcpt_N.)
IPR009135 (Tyr_prot_kinase_VEGFR1_rcpt_N.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1FLT 1QTY 1RV6 2XAC 3HNG
CREDO 1FLT 1QTY 1RV6 2XAC 3HNG
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