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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1868
Target Type SINGLE PROTEIN
Preferred Name Vascular endothelial growth factor receptor 1
Synonyms FLT | FLT | FLT-1 | FLT1 | FRT | Fms-like tyrosine kinase 1 | Tyrosine-protein kinase FRT | Tyrosine-protein kinase receptor FLT | VEGFR-1 | VEGFR1 | Vascular endothelial growth factor receptor 1 | Vascular permeability factor receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase vegfr family

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor receptor 1 SINGLE PROTEIN P17948

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111480 Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) SELECTIVITY GROUP
CHEMBL2095227 Vascular endothelial growth factor receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545026 Famitinib Vascular endothelial growth factor receptor 1 inhibitor 3 ClinicalTrials DOI PubMed
CHEMBL403989 TG100-801 Vascular endothelial growth factor receptor 1 inhibitor 2 PubMed PubMed PubMed
CHEMBL587723 AEE-788 Vascular endothelial growth factor receptor 1 inhibitor 2 PubMed
CHEMBL1743030 ICRUCUMAB Vascular endothelial growth factor receptor 1 antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102755
Ensembl ENSG00000102755
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005021 (vascular endothelial growth factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0036326 (VEGF-A-activated receptor activity)
GO:0036327 (VEGF-B-activated receptor activity)
GO:0036332 (placental growth factor-activated receptor activity)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0002548 (monocyte chemotaxis)
GO:0006468 (protein phosphorylation)
GO:0006935 (chemotaxis)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008284 (positive regulation of cell proliferation)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030522 (intracellular receptor signaling pathway)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0036323 (vascular endothelial growth factor receptor-1 signaling pathway)
GO:0038084 (vascular endothelial growth factor signaling pathway)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045766 (positive regulation of angiogenesis)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048514 (blood vessel morphogenesis)
GO:0048598 (embryonic morphogenesis)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
Wikipedia FLT1

Target Cross References - Protein

canSAR P17948
Human Protein Atlas ENSG00000102755
IntAct P17948
Guide to Pharmacology 1812
Open Targets ENSG00000102755
PharmGKB PA28180
Pharos P17948 (Tclin)
Reactome R-HSA-194306 (Neurophilin interactions with VEGF and VEGFR.)
R-HSA-195399 (VEGF binds to VEGFR leading to receptor dimerization.)
UniProt A3E342 A3E344 A8KA71 B0LPF1 B2BF46 B2BF47 B2BF48 B3FR89 B5A923 F5H5L6 O60722 P16057 P17948 Q12954

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR009135 (VEGFR1_rcpt.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013106 (Ig_V-set.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00047 (ig)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1FLT 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89
CREDO 1FLT 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5ABD 5EX3 5T89
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