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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1868
Target Type SINGLE PROTEIN
Preferred Name Vascular endothelial growth factor receptor 1
Synonyms FLT | FLT | FLT-1 | FLT1 | FRT | Fms-like tyrosine kinase 1 | Tyrosine-protein kinase FRT | Tyrosine-protein kinase receptor FLT | VEGFR-1 | VEGFR1 | Vascular endothelial growth factor receptor 1 | Vascular permeability factor receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase vegfr family

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor receptor 1 SINGLE PROTEIN P17948

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2095227 Vascular endothelial growth factor receptor PROTEIN FAMILY
CHEMBL2111480 Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR) SELECTIVITY GROUP

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL403989 TG100-801 Vascular endothelial growth factor receptor 1 inhibitor 2 PubMed PubMed PubMed
CHEMBL587723 AEE-788 Vascular endothelial growth factor receptor 1 inhibitor 2 PubMed
CHEMBL3545026 Famitinib Vascular endothelial growth factor receptor 1 inhibitor 2 ClinicalTrials DOI PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000102755
Ensembl ENSG00000102755
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005021 (vascular endothelial growth factor-activated receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0036326 (VEGF-A-activated receptor activity)
GO:0036327 (VEGF-B-activated receptor activity)
GO:0036332 (placental growth factor-activated receptor activity)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0002548 (monocyte chemotaxis)
GO:0006468 (protein phosphorylation)
GO:0006935 (chemotaxis)
GO:0006940 (regulation of smooth muscle contraction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0008284 (positive regulation of cell proliferation)
GO:0010863 (positive regulation of phospholipase C activity)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030522 (intracellular receptor signaling pathway)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0036323 (vascular endothelial growth factor receptor-1 signaling pathway)
GO:0038084 (vascular endothelial growth factor signaling pathway)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0045766 (positive regulation of angiogenesis)
GO:0046777 (protein autophosphorylation)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048514 (blood vessel morphogenesis)
GO:0048598 (embryonic morphogenesis)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
Wikipedia FLT1

Target Cross References - Protein

canSAR P17948
Human Protein Atlas ENSG00000102755
IntAct P17948
Guide to Pharmacology 1812
Open Targets ENSG00000102755
PharmGKB PA28180
Pharos P17948 (Tclin)
Reactome R-HSA-194306 (Neurophilin interactions with VEGF and VEGFR.)
R-HSA-195399 (VEGF binds to VEGFR leading to receptor dimerization.)
UniProt A3E342 A3E344 A8KA71 B0LPF1 B2BF46 B2BF47 B2BF48 B3FR89 B5A923 F5H5L6 O60722 P16057 P17948 Q12954

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR009135 (VEGFR1_rcpt.)
IPR011009 (Kinase-like_dom.)
IPR013098 (Ig_I-set.)
IPR013106 (Ig_V-set.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00047 (ig)
PF07679 (I-set)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1FLT 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5EX3
CREDO 1FLT 1QTY 1RV6 2XAC 3HNG 4CKV 4CL7 5EX3
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