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Target Report Card

Target Name and Classification

Target ID CHEMBL1866
Target Type SINGLE PROTEIN
Preferred Name Voltage-gated potassium channel subunit Kv7.1
Synonyms IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 | KCNA8 | KCNA9 | KCNQ1 | KQT-like 1 | KVLQT1 | Potassium voltage-gated channel subfamily KQT member 1 | Voltage-gated potassium channel subunit Kv7.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > potassium channels > voltage-gated potassium channel

Target Components

Component Description Relationship Accession
Potassium voltage-gated channel subfamily KQT member 1 SINGLE PROTEIN P51787

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2221347 Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) PROTEIN COMPLEX
CHEMBL2362996 Voltage-gated potassium channel PROTEIN FAMILY
CHEMBL3430890 Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 PROTEIN COMPLEX
CHEMBL2363063 KCNQ (Kv7) potassium channel PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000053918
Ensembl ENSG00000053918
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005764 (lysosome)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0008076 (voltage-gated potassium channel complex)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0034702 (ion channel complex)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005249 (voltage-gated potassium channel activity)
GO:0005251 (delayed rectifier potassium channel activity)
GO:0005267 (potassium channel activity)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0005546 (phosphatidylinositol-4,5-bisphosphate binding)
GO:0008157 (protein phosphatase 1 binding)
GO:0015271 (outward rectifier potassium channel activity)
GO:0034236 (protein kinase A catalytic subunit binding)
GO:0034237 (protein kinase A regulatory subunit binding)
GO:0044325 (ion channel binding)
GO:0086008 (voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)
GO:0086089 (voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization)
GO:0097110 (scaffold protein binding)
GO:1902282 (voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)
GO Biological Process GO:0002230 (positive regulation of defense response to virus by host)
GO:0006349 (regulation of gene expression by genetic imprinting)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0007605 (sensory perception of sound)
GO:0008016 (regulation of heart contraction)
GO:0010460 (positive regulation of heart rate)
GO:0016458 (gene silencing)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035690 (cellular response to drug)
GO:0048839 (inner ear development)
GO:0050892 (intestinal absorption)
GO:0055085 (transmembrane transport)
GO:0060048 (cardiac muscle contraction)
GO:0060306 (regulation of membrane repolarization)
GO:0060307 (regulation of ventricular cardiac muscle cell membrane repolarization)
GO:0060372 (regulation of atrial cardiac muscle cell membrane repolarization)
GO:0060452 (positive regulation of cardiac muscle contraction)
GO:0060453 (regulation of gastric acid secretion)
GO:0061337 (cardiac conduction)
GO:0070293 (renal absorption)
GO:0071320 (cellular response to cAMP)
GO:0071435 (potassium ion export)
GO:0071805 (potassium ion transmembrane transport)
GO:0071872 (cellular response to epinephrine stimulus)
GO:0072358 (cardiovascular system development)
GO:0086005 (ventricular cardiac muscle cell action potential)
GO:0086009 (membrane repolarization)
GO:0086011 (membrane repolarization during action potential)
GO:0086013 (membrane repolarization during cardiac muscle cell action potential)
GO:0086014 (atrial cardiac muscle cell action potential)
GO:0086091 (regulation of heart rate by cardiac conduction)
GO:0097623 (potassium ion export across plasma membrane)
GO:0098792 (xenophagy)
GO:0098915 (membrane repolarization during ventricular cardiac muscle cell action potential)
GO:1901381 (positive regulation of potassium ion transmembrane transport)
GO:1902260 (negative regulation of delayed rectifier potassium channel activity)
GO:1903817 (negative regulation of voltage-gated potassium channel activity)
Wikipedia KvLQT1

Target Cross References - Protein

canSAR P51787
CGD Long QT syndrome-1; Jervell and Lange-Nielsen syndrome 1; Short QT syndrome 2; Atrial fibrillation, familial 3
Human Protein Atlas ENSG00000053918
IntAct P51787
Guide to Pharmacology 560
Open Targets ENSG00000053918
PharmGKB PA223
Pharos P51787 (Tclin)
Reactome R-HSA-1296072 (Voltage gated Potassium channels.)
R-HSA-5576890 (Phase 3 - rapid repolarisation.)
R-HSA-5576893 (Phase 2 - plateau phase.)
UniProt O00347 O60607 O94787 P51787 Q14D14 Q7Z6G9 Q92960 Q9UMN8 Q9UMN9

Target Cross References - Domain

InterPro IPR003937 (K_chnl_volt-dep_KCNQ.)
IPR005821 (Ion_trans_dom.)
IPR005827 (K_chnl_volt-dep_KCQN1.)
IPR013821 (K_chnl_volt-dep_KCNQ_C.)
IPR028325 (VG_K_chnl.)
Pfam PF00520 (Ion_trans)
PF03520 (KCNQ_channel)

Target Cross References - Structure

PDBe 3BJ4 3HFC 3HFE 4UMO 4V0C
CREDO 3BJ4 3HFC 3HFE 4UMO 4V0C
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