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Target Report Card

Target Name and Classification

Target ID CHEMBL1865
Preferred Name Histone deacetylase 6
Synonyms HD6 | HDAC6 | Histone deacetylase 6 | KIAA0901
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iib

Target Components

Component Description Relationship Accession
Histone deacetylase 6 SINGLE PROTEIN Q9UBN7

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 6 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000094631
Ensembl ENSG00000094631
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005771 (multivesicular body)
GO:0005829 (cytosol)
GO:0005874 (microtubule)
GO:0005875 (microtubule associated complex)
GO:0005881 (cytoplasmic microtubule)
GO:0005901 (caveola)
GO:0016234 (inclusion body)
GO:0016235 (aggresome)
GO:0030286 (dynein complex)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031252 (cell leading edge)
GO:0042995 (cell projection)
GO:0043204 (perikaryon)
GO:0043234 (protein complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001047 (core promoter binding)
GO:0003779 (actin binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008017 (microtubule binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0031593 (polyubiquitin binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0042826 (histone deacetylase binding)
GO:0042903 (tubulin deacetylase activity)
GO:0043014 (alpha-tubulin binding)
GO:0043130 (ubiquitin binding)
GO:0046872 (metal ion binding)
GO:0048156 (tau protein binding)
GO:0048487 (beta-tubulin binding)
GO:0051787 (misfolded protein binding)
GO:0051879 (Hsp90 protein binding)
GO:0070840 (dynein complex binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0006511 (ubiquitin-dependent protein catabolic process)
GO:0006515 (misfolded or incompletely synthesized protein catabolic process)
GO:0006886 (intracellular protein transport)
GO:0006914 (autophagy)
GO:0006996 (organelle organization)
GO:0007026 (negative regulation of microtubule depolymerization)
GO:0009636 (response to toxic substance)
GO:0009967 (positive regulation of signal transduction)
GO:0010033 (response to organic substance)
GO:0010469 (regulation of receptor activity)
GO:0010506 (regulation of autophagy)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010727 (negative regulation of hydrogen peroxide metabolic process)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0016236 (macroautophagy)
GO:0016568 (chromatin modification)
GO:0016575 (histone deacetylation)
GO:0031647 (regulation of protein stability)
GO:0032418 (lysosome localization)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0035967 (cellular response to topologically incorrect protein)
GO:0040029 (regulation of gene expression, epigenetic)
GO:0043162 (ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)
GO:0043241 (protein complex disassembly)
GO:0043242 (negative regulation of protein complex disassembly)
GO:0045598 (regulation of fat cell differentiation)
GO:0045861 (negative regulation of proteolysis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0051354 (negative regulation of oxidoreductase activity)
GO:0051646 (mitochondrion localization)
GO:0051788 (response to misfolded protein)
GO:0060632 (regulation of microtubule-based movement)
GO:0060765 (regulation of androgen receptor signaling pathway)
GO:0070201 (regulation of establishment of protein localization)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070842 (aggresome assembly)
GO:0070845 (polyubiquitinated misfolded protein transport)
GO:0070846 (Hsp90 deacetylation)
GO:0070848 (response to growth factor)
GO:0070932 (histone H3 deacetylation)
GO:0071218 (cellular response to misfolded protein)
GO:0090035 (positive regulation of chaperone-mediated protein complex assembly)
GO:0090042 (tubulin deacetylation)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:1901300 (positive regulation of hydrogen peroxide-mediated programmed cell death)
GO:1903146 (regulation of mitophagy)
Wikipedia HDAC6

Target Cross References - Protein

Human Protein Atlas ENSG00000094631
IntAct Q9UBN7
Guide to Pharmacology 2618
Open Targets ENSG00000094631
PharmGKB PA29231
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3371511 (HSF1 activation.)
R-HSA-5617833 (Cilium Assembly.)
UniProt O94975 Q6NT75 Q7L3E5 Q96CY0 Q9UBN7

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR001607 (Znf_UBP.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR023801 (His_deacetylse_dom.)
Pfam PF00850 (Hist_deacetyl)
PF02148 (zf-UBP)

Target Cross References - Structure

PDBe 3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9