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Target Report Card

Target Name and Classification

Target ID CHEMBL1865
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 6
Synonyms HD6 | HDAC6 | Histone deacetylase 6 | KIAA0901
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iib

Target Components

Component Description Relationship Accession
Histone deacetylase 6 SINGLE PROTEIN Q9UBN7

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430896 Histone deacetylase 1/2/3/6 PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 6 inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000094631
Ensembl ENSG00000094631
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005771 (multivesicular body)
GO:0005829 (cytosol)
GO:0005874 (microtubule)
GO:0005875 (microtubule associated complex)
GO:0005881 (cytoplasmic microtubule)
GO:0005901 (caveola)
GO:0016234 (inclusion body)
GO:0016235 (aggresome)
GO:0030286 (dynein complex)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0031252 (cell leading edge)
GO:0032991 (macromolecular complex)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043204 (perikaryon)
GO:0044297 (cell body)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0001047 (core promoter binding)
GO:0003779 (actin binding)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008017 (microtubule binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0031593 (polyubiquitin binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0042826 (histone deacetylase binding)
GO:0042903 (tubulin deacetylase activity)
GO:0043014 (alpha-tubulin binding)
GO:0043130 (ubiquitin binding)
GO:0046872 (metal ion binding)
GO:0048156 (tau protein binding)
GO:0048487 (beta-tubulin binding)
GO:0051787 (misfolded protein binding)
GO:0051879 (Hsp90 protein binding)
GO:0070840 (dynein complex binding)
GO Biological Process GO:0000209 (protein polyubiquitination)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0006511 (ubiquitin-dependent protein catabolic process)
GO:0006515 (misfolded or incompletely synthesized protein catabolic process)
GO:0006886 (intracellular protein transport)
GO:0006914 (autophagy)
GO:0007026 (negative regulation of microtubule depolymerization)
GO:0009636 (response to toxic substance)
GO:0009967 (positive regulation of signal transduction)
GO:0010033 (response to organic substance)
GO:0010469 (regulation of receptor activity)
GO:0010506 (regulation of autophagy)
GO:0010634 (positive regulation of epithelial cell migration)
GO:0010727 (negative regulation of hydrogen peroxide metabolic process)
GO:0010870 (positive regulation of receptor biosynthetic process)
GO:0016241 (regulation of macroautophagy)
GO:0016575 (histone deacetylation)
GO:0031647 (regulation of protein stability)
GO:0032418 (lysosome localization)
GO:0032461 (positive regulation of protein oligomerization)
GO:0032984 (protein-containing complex disassembly)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0034983 (peptidyl-lysine deacetylation)
GO:0035967 (cellular response to topologically incorrect protein)
GO:0040029 (regulation of gene expression, epigenetic)
GO:0043162 (ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)
GO:0043242 (negative regulation of protein complex disassembly)
GO:0045598 (regulation of fat cell differentiation)
GO:0045861 (negative regulation of proteolysis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0048668 (collateral sprouting)
GO:0051354 (negative regulation of oxidoreductase activity)
GO:0051646 (mitochondrion localization)
GO:0051788 (response to misfolded protein)
GO:0060271 (cilium morphogenesis)
GO:0060632 (regulation of microtubule-based movement)
GO:0060765 (regulation of androgen receptor signaling pathway)
GO:0060997 (dendritic spine morphogenesis)
GO:0061734 (parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)
GO:0070201 (regulation of establishment of protein localization)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0070842 (aggresome assembly)
GO:0070845 (polyubiquitinated misfolded protein transport)
GO:0070846 (Hsp90 deacetylation)
GO:0070848 (response to growth factor)
GO:0070932 (histone H3 deacetylation)
GO:0071218 (cellular response to misfolded protein)
GO:0090035 (positive regulation of chaperone-mediated protein complex assembly)
GO:0090042 (tubulin deacetylation)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:1901300 (positive regulation of hydrogen peroxide-mediated programmed cell death)
GO:1903146 (regulation of mitophagy)
Wikipedia HDAC6

Target Cross References - Protein

canSAR Q9UBN7
Human Protein Atlas ENSG00000094631
IntAct Q9UBN7
Guide to Pharmacology 2618
Open Targets ENSG00000094631
PharmGKB PA29231
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3371511 (HSF1 activation.)
R-HSA-5617833 (Cilium Assembly.)
R-HSA-8878166 (Transcriptional regulation by RUNX2.)
R-HSA-8940973 (RUNX2 regulates osteoblast differentiation.)
UniProt O94975 Q6NT75 Q7L3E5 Q96CY0 Q9UBN7

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR001607 (Znf_UBP.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)
PF02148 (zf-UBP)

Target Cross References - Structure

PDBe 3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB
CREDO 3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB
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