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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1864
Target Type SINGLE PROTEIN
Preferred Name Thrombopoietin receptor
Synonyms CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | Proto-oncogene c-Mpl | TPO-R | TPOR | Thrombopoietin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Thrombopoietin receptor SINGLE PROTEIN P40238

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201832 ROMIPLOSTIM Thrombopoietin receptor agonist 4 DailyMed
CHEMBL3989691 ELTROMBOPAG OLAMINE Thrombopoietin receptor agonist 4 DailyMed
CHEMBL2103883 AVATROMBOPAG Thrombopoietin receptor agonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117400
Ensembl ENSG00000117400
GO Cellular Component GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004896 (cytokine receptor activity)
GO:0005515 (protein binding)
GO:0038164 (thrombopoietin receptor activity)
GO Biological Process GO:0001780 (neutrophil homeostasis)
GO:0007166 (cell surface receptor signaling pathway)
GO:0008283 (cell proliferation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0035702 (monocyte homeostasis)
GO:0038163 (thrombopoietin-mediated signaling pathway)
GO:0050671 (positive regulation of lymphocyte proliferation)
GO:0070527 (platelet aggregation)
GO:0071456 (cellular response to hypoxia)
GO:1905221 (positive regulation of platelet formation)
GO:1990959 (eosinophil homeostasis)
GO:1990960 (basophil homeostasis)
Wikipedia Thrombopoietin_receptor

Target Cross References - Protein

canSAR P40238
CGD Thrombocythemia 2; Amegakaryocytic thrombocytopenia
Human Protein Atlas ENSG00000117400
IntAct P40238
Guide to Pharmacology 1722
Open Targets ENSG00000117400
PharmGKB PA30923
Reactome R-HSA-76009 (Platelet Aggregation (Plug Formation).)
UniProt P40238 Q5JUZ0

Target Cross References - Domain

InterPro IPR003528 (Long_hematopoietin_rcpt_CS.)
IPR003961 (FN3_dom.)
IPR013783 (Ig-like_fold.)
IPR015152 (Growth/epo_recpt_lig-bind.)
IPR036116 (FN3_sf.)
Pfam PF00041 (fn3)
PF09067 (EpoR_lig-bind)
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