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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1864
Target Type SINGLE PROTEIN
Preferred Name Thrombopoietin receptor
Synonyms CD_antigen=CD110 | MPL | Myeloproliferative leukemia protein | Proto-oncogene c-Mpl | TPO-R | TPOR | Thrombopoietin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Thrombopoietin receptor SINGLE PROTEIN P40238

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL461806 ELTROMBOPAG OLAMINE Thrombopoietin receptor agonist DailyMed
CHEMBL1201832 ROMIPLOSTIM Thrombopoietin receptor agonist DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Expression Atlas ENSG00000117400
Ensembl ENSG00000117400
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004896 (cytokine receptor activity)
GO Biological Process GO:0008283 (cell proliferation)
GO:0030168 (platelet activation)
Wikipedia Thrombopoietin_receptor

Target Cross References - Protein

canSAR P40238
CGD Thrombocythemia 2; Amegakaryocytic thrombocytopenia
Human Protein Atlas ENSG00000117400
Guide to Pharmacology 1722 (Thrombopoietin receptor)
PharmGKB PA30923
Reactome REACT_604 (Hemostasis.)
UniProt P40238 Q5JUZ0

Target Cross References - Domain

InterPro IPR003528 (Long_hematopoietin_rcpt_CS.)
IPR003961 (FN_III.)
IPR008957 (Fibronectin_III_dom.)
IPR013783 (Ig-like_fold.)
IPR015152 (Growth/epo_recpt_lig-bind.)
Pfam PF00041 (fn3)
PF09067 (EpoR_lig-bind)
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