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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1862
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase ABL
Synonyms ABL | ABL1 | Abelson murine leukemia viral oncogene homolog 1 | Abelson tyrosine-protein kinase 1 | JTK7 | Proto-oncogene c-Abl | Tyrosine-protein kinase ABL1 | p150
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ABL1 SINGLE PROTEIN P00519

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096618 Bcr/Abl fusion protein CHIMERIC PROTEIN
CHEMBL2111414 Tyrosine-protein kinase ABL PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL288441 BOSUTINIB Tyrosine-protein kinase ABL inhibitor 4 Expert
CHEMBL1421 DASATINIB Tyrosine-protein kinase ABL inhibitor 4 DailyMed
CHEMBL1642 IMATINIB MESYLATE Tyrosine-protein kinase ABL inhibitor 4 DailyMed
CHEMBL1201740 NILOTINIB HYDROCHLORIDE MONOHYDRATE Tyrosine-protein kinase ABL inhibitor 4 DailyMed
CHEMBL1946170 REGORAFENIB Tyrosine-protein kinase ABL inhibitor 4 Expert
CHEMBL2105708 PONATINIB HYDROCHLORIDE Tyrosine-protein kinase ABL inhibitor 4 DailyMed PubMed
CHEMBL217092 SARACATINIB Tyrosine-protein kinase ABL inhibitor 3 PubMed
CHEMBL3545413 Flumatinib Tyrosine-protein kinase ABL inhibitor 3 PubMed PubMed
CHEMBL206834 BAFETINIB Tyrosine-protein kinase ABL inhibitor 2 PubMed
CHEMBL495727 AT-9283 Tyrosine-protein kinase ABL inhibitor 2 PubMed
CHEMBL1738757 REBASTINIB Tyrosine-protein kinase ABL inhibitor 2 PubMed
CHEMBL3545150 AZM-475271 Tyrosine-protein kinase ABL 2
CHEMBL1908397 KW-2449 Tyrosine-protein kinase ABL inhibitor 1
CHEMBL3545085 XL-228 Tyrosine-protein kinase ABL inhibitor 1 DOI Other
CHEMBL3545115 ABL-001 Tyrosine-protein kinase ABL inhibitor 1 Other Other
CHEMBL3545177 AZD-0424 Tyrosine-protein kinase ABL inhibitor 1 ClinicalTrials PubMed
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000097007
Ensembl ENSG00000097007
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0015629 (actin cytoskeleton)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0031965 (nuclear membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0003785 (actin monomer binding)
GO:0004515 (nicotinate-nucleotide adenylyltransferase activity)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005102 (receptor binding)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0017124 (SH3 domain binding)
GO:0019905 (syntaxin binding)
GO:0030145 (manganese ion binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070064 (proline-rich region binding)
GO Biological Process GO:0000115 (regulation of transcription involved in S phase of mitotic cell cycle)
GO:0000724 (double-strand break repair via homologous recombination)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006281 (DNA repair)
GO:0006298 (mismatch repair)
GO:0006302 (double-strand break repair)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006464 (cellular protein modification process)
GO:0006914 (autophagy)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0006979 (response to oxidative stress)
GO:0007050 (cell cycle arrest)
GO:0007067 (mitotic nuclear division)
GO:0007155 (cell adhesion)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007411 (axon guidance)
GO:0007596 (blood coagulation)
GO:0008630 (DNA damage response, signal transduction resulting in induction of apoptosis)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0010506 (regulation of autophagy)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0030100 (regulation of endocytosis)
GO:0030154 (cell differentiation)
GO:0030155 (regulation of cell adhesion)
GO:0030516 (regulation of axon extension)
GO:0031113 (regulation of microtubule polymerization)
GO:0032956 (regulation of actin cytoskeleton organization)
GO:0034599 (cellular response to oxidative stress)
GO:0035791 (platelet-derived growth factor receptor-beta signaling pathway)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042127 (regulation of cell proliferation)
GO:0042692 (muscle cell differentiation)
GO:0042770 (signal transduction in response to DNA damage)
GO:0043065 (positive regulation of apoptotic process)
GO:0045087 (innate immune response)
GO:0045184 (establishment of protein localization)
GO:0048008 (platelet-derived growth factor receptor signaling pathway)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0051444 (negative regulation of ubiquitin-protein transferase activity)
GO:0051882 (mitochondrial depolarization)
GO:0071901 (negative regulation of protein serine/threonine kinase activity)
GO:1900275 (negative regulation of phospholipase C activity)
GO:1903351 (cellular response to dopamine)
GO:1904528 (positive regulation of microtubule binding)
GO:1904531 (positive regulation of actin filament binding)
GO:2000145 (regulation of cell motility)
GO:2000249 (regulation of actin cytoskeleton reorganization)
GO:2001020 (regulation of response to DNA damage stimulus)
Wikipedia ABL_(gene) Abl_gene

Target Cross References - Protein

canSAR P00519
Human Protein Atlas ENSG00000097007
IntAct P00519
PharmGKB PA24413
UniProt A3KFJ3 P00519 Q13869 Q13870 Q16133 Q17R61 Q45F09

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015015 (F-actin_binding.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
PF08919 (F_actin_bind)

Target Cross References - Structure

PDBe 1BBZ 1OPL 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU More...
CREDO 1BBZ 1OPL 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU More...
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