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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1862
Target Type SINGLE PROTEIN
Preferred Name Tyrosine-protein kinase ABL
Synonyms ABL | ABL1 | Abelson murine leukemia viral oncogene homolog 1 | Abelson tyrosine-protein kinase 1 | JTK7 | Proto-oncogene c-Abl | Tyrosine-protein kinase ABL1 | p150
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase abl family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase ABL1 SINGLE PROTEIN P00519

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096618 Bcr/Abl fusion protein CHIMERIC PROTEIN
CHEMBL2111414 Tyrosine-protein kinase ABL PROTEIN FAMILY

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL288441 BOSUTINIB Tyrosine-protein kinase ABL inhibitor Expert
CHEMBL1421 DASATINIB Tyrosine-protein kinase ABL inhibitor DailyMed
CHEMBL1642 IMATINIB MESYLATE Tyrosine-protein kinase ABL inhibitor DailyMed
CHEMBL1201740 NILOTINIB HYDROCHLORIDE MONOHYDRATE Tyrosine-protein kinase ABL inhibitor DailyMed
CHEMBL2105708 PONATINIB HYDROCHLORIDE Tyrosine-protein kinase ABL inhibitor DailyMed PubMed
CHEMBL1946170 REGORAFENIB Tyrosine-protein kinase ABL inhibitor Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000097007
Ensembl ENSG00000097007
GO Cellular Component GO:0005730 (nucleolus)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0031965 (nuclear membrane)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0003677 (DNA binding)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0008022 (protein C-terminus binding)
GO:0017124 (SH3 domain binding)
GO:0030145 (manganese ion binding)
GO:0051019 (mitogen-activated protein kinase binding)
GO:0070064 (proline-rich region binding)
GO Biological Process GO:0000115 (regulation of transcription involved in S phase of mitotic cell cycle)
GO:0006298 (mismatch repair)
GO:0006975 (DNA damage induced protein phosphorylation)
GO:0007155 (cell adhesion)
GO:0007411 (axon guidance)
GO:0007596 (blood coagulation)
GO:0008630 (DNA damage response, signal transduction resulting in induction of apoptosis)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030036 (actin cytoskeleton organization)
GO:0042692 (muscle cell differentiation)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051353 (positive regulation of oxidoreductase activity)
GO:0071901 (negative regulation of protein serine/threonine kinase activity)
Wikipedia Abl_gene

Target Cross References - Protein

canSAR P00519
Human Protein Atlas ENSG00000097007
IntAct P00519
Guide to Pharmacology 1923 (ABL proto-oncogene 1, non-receptor tyrosine kinase)
PharmGKB PA24413
Reactome REACT_18266 (Axon guidance.)
REACT_21303 (Myogenesis.)
REACT_604 (Hemostasis.)
UniProt A3KFJ3 P00519 Q13869 Q13870 Q16133 Q17R61 Q45F09

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015015 (F-actin_binding.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)
PF08919 (F_actin_bind)

Target Cross References - Structure

PDBe 1BBZ 1OPL 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU More...
CREDO 1BBZ 1OPL 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU More...
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