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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1860
Target Type SINGLE PROTEIN
Preferred Name Thyroid hormone receptor alpha
Synonyms EAR-7 | EAR7 | ERBA1 | NR1A1 | Nuclear receptor subfamily 1 group A member 1 | THRA | THRA1 | THRA2 | Thyroid hormone receptor alpha | V-erbA-related protein 7 | c-erbA-1 | c-erbA-alpha
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group a > nuclear hormone receptor subfamily 1 group a member 1

Target Components

Component Description Relationship Accession
Thyroid hormone receptor alpha SINGLE PROTEIN P10827

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111462 Thyroid hormone receptor PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000126351
Ensembl ENSG00000126351
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO Molecular Function GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0002153 (steroid receptor RNA activator RNA binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003727 (single-stranded RNA binding)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0004887 (thyroid hormone receptor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0017025 (TBP-class protein binding)
GO:0019904 (protein domain specific binding)
GO:0031490 (chromatin DNA binding)
GO:0032403 (protein complex binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044213 (intronic transcription regulatory region DNA binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO:0070324 (thyroid hormone binding)
GO Biological Process GO:0001502 (cartilage condensation)
GO:0001503 (ossification)
GO:0001822 (kidney development)
GO:0001889 (liver development)
GO:0002155 (regulation of thyroid hormone mediated signaling pathway)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007420 (brain development)
GO:0007611 (learning or memory)
GO:0008016 (regulation of heart contraction)
GO:0008050 (female courtship behavior)
GO:0009409 (response to cold)
GO:0009755 (hormone-mediated signaling pathway)
GO:0009887 (organ morphogenesis)
GO:0010831 (positive regulation of myotube differentiation)
GO:0017055 (negative regulation of RNA polymerase II transcriptional preinitiation complex assembly)
GO:0030218 (erythrocyte differentiation)
GO:0030324 (lung development)
GO:0030325 (adrenal gland development)
GO:0030522 (intracellular receptor signaling pathway)
GO:0030878 (thyroid gland development)
GO:0031667 (response to nutrient levels)
GO:0033032 (regulation of myeloid cell apoptotic process)
GO:0042493 (response to drug)
GO:0042994 (cytoplasmic sequestering of transcription factor)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045925 (positive regulation of female receptivity)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048565 (digestive tract development)
GO:0048568 (embryonic organ development)
GO:0050994 (regulation of lipid catabolic process)
GO:0060509 (Type I pneumocyte differentiation)
GO:2000143 (negative regulation of DNA-templated transcription, initiation)
Wikipedia Thyroid_hormone_receptor_alpha

Target Cross References - Protein

canSAR P10827
CGD Hypothyroidism, congenital, nongoitrous, 6
Human Protein Atlas ENSG00000126351
IntAct P10827
Guide to Pharmacology 588
Open Targets ENSG00000126351
PharmGKB PA36507
Pharos P10827 (Tclin)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt A8K3B5 P10827 P21205 Q8N6A1 Q96H73

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR001728 (ThyrH_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
CREDO 1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX
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