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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1854
Preferred Name Luteinizing hormone/Choriogonadotropin receptor
Synonyms LCGR | LGR2 | LH/CG-R | LHCGR | LHR | LHRHR | LSH-R | Luteinizing hormone receptor | Lutropin-choriogonadotropic hormone receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > glycohormone receptor > glycohormone receptor

Target Components

Component Description Relationship Accession
Lutropin-choriogonadotropic hormone receptor SINGLE PROTEIN P22888

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201464 CHORIOGONADOTROPIN ALFA Luteinizing hormone/Choriogonadotropin receptor agonist 4 DailyMed
CHEMBL1201419 LUTROPIN ALFA Luteinizing hormone/Choriogonadotropin receptor agonist 4 FDA PubMed
CHEMBL1201509 GONADOTROPIN, CHORIONIC Luteinizing hormone/Choriogonadotropin receptor agonist 4 DailyMed
CHEMBL1201697 LH (MENOTROPINS) Luteinizing hormone/Choriogonadotropin receptor agonist 4 FDA IUPHAR
CHEMBL2108427 MENOTROPINS Luteinizing hormone/Choriogonadotropin receptor agonist 4 FDA IUPHAR

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138039
Ensembl ENSG00000138039
GO Cellular Component GO:0005768 (endosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004963 (follicle-stimulating hormone receptor activity)
GO:0004964 (luteinizing hormone receptor activity)
GO:0008528 (G-protein coupled peptide receptor activity)
GO:0016500 (protein-hormone receptor activity)
GO:0035472 (choriogonadotropin hormone receptor activity)
GO:0038106 (choriogonadotropin hormone binding)
GO Biological Process GO:0001545 (primary ovarian follicle growth)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0008584 (male gonad development)
GO:0009755 (hormone-mediated signaling pathway)
GO:0030539 (male genitalia development)
GO:0032962 (positive regulation of inositol trisphosphate biosynthetic process)
GO:0042699 (follicle-stimulating hormone signaling pathway)
GO:0042700 (luteinizing hormone signaling pathway)
GO:0045670 (regulation of osteoclast differentiation)
GO:0045762 (positive regulation of adenylate cyclase activity)
GO:0050890 (cognition)
GO:0071371 (cellular response to gonadotropin stimulus)
GO:0071373 (cellular response to luteinizing hormone stimulus)
Wikipedia Luteinizing_hormone/choriogonadotropin_receptor

Target Cross References - Protein

canSAR P22888
CGD Leydig cell hypoplasia type I; Leydig cell hypoplasia type II; Luteinizing hormone resistance, female; Precocious puberty, male
Human Protein Atlas ENSG00000138039
Guide to Pharmacology 254
Open Targets ENSG00000138039
PharmGKB PA30357
Pharos P22888 (Tclin)
Reactome R-HSA-375281 (Hormone ligand-binding receptors.)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt P22888 Q14751 Q15996 Q9UEW9

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002131 (Gphrmn_rcpt_fam.)
IPR002273 (LSH_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR026906 (LRR_5.)
IPR032675 (LRR_dom_sf.)
Pfam PF00001 (7tm_1)
PF13306 (LRR_5)