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Target Report Card

Target Name and Classification

Target ID CHEMBL1846
Preferred Name Ryanodine receptor 1
Synonyms RYDR | RYR-1 | RYR1 | RyR1 | Ryanodine receptor 1 | Skeletal muscle calcium release channel | Skeletal muscle ryanodine receptor | Skeletal muscle-type ryanodine receptor | Type 1 ryanodine receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > ryanodine receptor

Target Components

Component Description Relationship Accession
Ryanodine receptor 1 SINGLE PROTEIN P21817

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL928 DANTROLENE SODIUM Ryanodine receptor 1 antagonist 4 PubMed PubMed PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000196218
Ensembl ENSG00000196218
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005790 (smooth endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005938 (cell cortex)
GO:0014701 (junctional sarcoplasmic reticulum membrane)
GO:0014802 (terminal cisterna)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016529 (sarcoplasmic reticulum)
GO:0030314 (junctional membrane complex)
GO:0030315 (T-tubule)
GO:0031674 (I band)
GO:0033017 (sarcoplasmic reticulum membrane)
GO:0043234 (protein complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0002020 (protease binding)
GO:0005216 (ion channel activity)
GO:0005219 (ryanodine-sensitive calcium-release channel activity)
GO:0005245 (voltage-gated calcium channel activity)
GO:0005262 (calcium channel activity)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0005516 (calmodulin binding)
GO:0015278 (calcium-release channel activity)
GO:0019899 (enzyme binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0003151 (outflow tract morphogenesis)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006816 (calcium ion transport)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006936 (muscle contraction)
GO:0007275 (multicellular organism development)
GO:0014808 (release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)
GO:0031000 (response to caffeine)
GO:0034220 (ion transmembrane transport)
GO:0043588 (skin development)
GO:0043931 (ossification involved in bone maturation)
GO:0048741 (skeletal muscle fiber development)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051480 (regulation of cytosolic calcium ion concentration)
GO:0055085 (transmembrane transport)
GO:0070588 (calcium ion transmembrane transport)
GO:0071313 (cellular response to caffeine)
GO:1903779 (regulation of cardiac conduction)
Wikipedia RYR1

Target Cross References - Protein

canSAR P21817
CGD Malignant hyperthermia, susceptibility 1; Central core disease; Minicore myopathy; Multicore myopathy; Minicore myopathy with external ophthalmoplegia; Centronuclear myopathy (individuals with these conditions may also be at risk of malignant hyperthermia)
Human Protein Atlas ENSG00000196218
IntAct P21817
Guide to Pharmacology 747
Open Targets ENSG00000196218
PharmGKB PA34896
Pharos P21817 (Tclin)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
R-HSA-5578775 (Ion homeostasis.)
UniProt P21817 Q16314 Q16368 Q9NPK1 Q9P1U4

Target Cross References - Domain

InterPro IPR000699 (RIH_dom.)
IPR001870 (B30.2/SPRY.)
IPR002048 (EF_hand_dom.)
IPR003032 (Ryanodine_rcpt.)
IPR003877 (SPRY_dom.)
IPR005821 (Ion_trans_dom.)
IPR009460 (Ryanrecept_TM4-6.)
IPR011992 (EF-hand-dom_pair.)
IPR013320 (ConA-like_dom.)
IPR013333 (Ryan_recept.)
IPR013662 (RIH_assoc-dom.)
IPR014821 (Ins145_P3_rcpt.)
IPR015925 (Ryanodine_recept-rel.)
IPR016093 (MIR_motif.)
IPR033215 (RyR1.)
Pfam PF00520 (Ion_trans)
PF00622 (SPRY)
PF02026 (RyR)
PF02815 (MIR)
PF06459 (RR_TM4-6)
PF08454 (RIH_assoc)
PF08709 (Ins145_P3_rec)
PF13833 (EF-hand_8)