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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1845
Preferred Name Sodium channel protein type I alpha subunit
Synonyms NAC1 | SCN1 | SCN1A | Sodium channel protein brain I subunit alpha | Sodium channel protein type 1 subunit alpha | Sodium channel protein type I subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 1 subunit alpha SINGLE PROTEIN P35498

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096682 Sodium channel alpha subunits; brain (Types I, II, III) PROTEIN FAMILY
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000144285
Ensembl ENSG00000144285
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO Molecular Function GO:0005248 (voltage-gated sodium channel activity)
Wikipedia Nav1.1

Target Cross References - Protein

canSAR P35498
CGD Migraine, familial hemiplegic 3
Human Protein Atlas ENSG00000144285
Guide to Pharmacology 578 (Nav1.1)
PharmGKB PA301
Reactome REACT_18266 (Axon guidance.)
UniProt P35498 Q16172 Q585T7 Q96LA3 Q9C008

Target Cross References - Domain

InterPro IPR000048 (IQ_motif_EF-hand-BS.)
IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans.)
IPR008051 (Na_channel_a1su.)
IPR010526 (Na_trans_assoc.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)