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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1845
Target Type SINGLE PROTEIN
Preferred Name Sodium channel protein type I alpha subunit
Synonyms NAC1 | SCN1 | SCN1A | Sodium channel protein brain I subunit alpha | Sodium channel protein type 1 subunit alpha | Sodium channel protein type I subunit alpha | Voltage-gated sodium channel subunit alpha Nav1.1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > voltage-gated ion channel > voltage-gated sodium channel

Target Components

Component Description Relationship Accession
Sodium channel protein type 1 subunit alpha SINGLE PROTEIN P35498

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096682 Sodium channel alpha subunits; brain (Types I, II, III) PROTEIN FAMILY
CHEMBL2331043 Sodium channel alpha subunit PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000144285
Ensembl ENSG00000144285
GO Cellular Component GO:0001518 (voltage-gated sodium channel complex)
GO:0005886 (plasma membrane)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030018 (Z disc)
GO:0030315 (T-tubule)
GO:0030424 (axon)
GO:0033268 (node of Ranvier)
GO:0034706 (sodium channel complex)
GO:0043025 (neuronal cell body)
GO:0043194 (axon initial segment)
GO Molecular Function GO:0005216 (ion channel activity)
GO:0005244 (voltage-gated ion channel activity)
GO:0005248 (voltage-gated sodium channel activity)
GO:0005272 (sodium channel activity)
GO:0031402 (sodium ion binding)
GO Biological Process GO:0001508 (action potential)
GO:0002230 (positive regulation of defense response to virus by host)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0007628 (adult walking behavior)
GO:0019227 (neuronal action potential propagation)
GO:0019228 (neuronal action potential)
GO:0034765 (regulation of ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0050884 (neuromuscular process controlling posture)
GO:0055085 (transmembrane transport)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0086010 (membrane depolarization during action potential)
GO:0098792 (xenophagy)
Wikipedia Nav1.1

Target Cross References - Protein

canSAR P35498
CGD Migraine, familial hemiplegic 3
Human Protein Atlas ENSG00000144285
IntAct P35498
Guide to Pharmacology 578
Open Targets ENSG00000144285
PharmGKB PA301
Pharos P35498 (Tclin)
Reactome R-HSA-445095 (Interaction between L1 and Ankyrins.)
R-HSA-5576892 (Phase 0 - rapid depolarisation.)
UniProt E9PG49 P35498 Q16172 Q585T7 Q8IUJ6 Q96LA3 Q9C008

Target Cross References - Domain

InterPro IPR001696 (Na_channel_asu.)
IPR005821 (Ion_trans_dom.)
IPR008051 (Na_channel_a1su.)
IPR010526 (Na_trans_assoc.)
IPR024583 (Na_trans_cytopl.)
IPR027359 (Channel_four-helix_dom.)
Pfam PF00520 (Ion_trans)
PF06512 (Na_trans_assoc)
PF11933 (Na_trans_cytopl)
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