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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1844
Target Type SINGLE PROTEIN
Preferred Name Macrophage colony stimulating factor receptor
Synonyms CD_antigen=CD115 | CSF-1 receptor | CSF-1-R | CSF-1R | CSF1R | FMS | M-CSF-R | Macrophage colony-stimulating factor 1 receptor | Proto-oncogene c-Fms
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase pdgfr family

Target Components

Component Description Relationship Accession
Macrophage colony-stimulating factor 1 receptor SINGLE PROTEIN P07333

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Macrophage colony stimulating factor receptor inhibitor DailyMed
CHEMBL1567 SUNITINIB MALATE Macrophage colony stimulating factor receptor inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182578
Ensembl ENSG00000182578
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0005011 (macrophage colony-stimulating factor receptor activity)
GO:0005524 (ATP binding)
GO:0019955 (cytokine binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organismal development)
GO:0008283 (cell proliferation)
Wikipedia Colony_stimulating_factor_1_receptor

Target Cross References - Protein

canSAR P07333
CGD Leukoencephalopathy, diffuse hereditary, with spheroids
Human Protein Atlas ENSG00000182578
IntAct P07333
Guide to Pharmacology 1806 (colony stimulating factor 1 receptor)
PharmGKB PA26936
UniProt D3DQG2 P07333 Q6LDW5 Q6LDY4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001824 (Tyr_prot_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR016243 (Tyr_prot_kinase_CSF1/PDGF_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF00047 (ig)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO
CREDO 2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO
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