ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1844
Target Type SINGLE PROTEIN
Preferred Name Macrophage colony stimulating factor receptor
Synonyms CD_antigen=CD115 | CSF-1 receptor | CSF-1-R | CSF-1R | CSF1R | FMS | M-CSF-R | Macrophage colony-stimulating factor 1 receptor | Proto-oncogene c-Fms
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase pdgfr family

Target Components

Component Description Relationship Accession
Macrophage colony-stimulating factor 1 receptor SINGLE PROTEIN P07333

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1567 SUNITINIB MALATE Macrophage colony stimulating factor receptor inhibitor 4 DailyMed
CHEMBL1201733 PAZOPANIB HYDROCHLORIDE Macrophage colony stimulating factor receptor inhibitor 4 DailyMed
CHEMBL101253 VATALANIB Macrophage colony stimulating factor receptor inhibitor 3 PubMed PubMed
CHEMBL223360 LINIFANIB Macrophage colony stimulating factor receptor inhibitor 3 PubMed PubMed
CHEMBL576982 QUIZARTINIB Macrophage colony stimulating factor receptor inhibitor 3 PubMed PubMed
CHEMBL3545158 PLX-3397 Macrophage colony stimulating factor receptor inhibitor 3 PubMed PubMed
CHEMBL482968 ENMD-2076 Macrophage colony stimulating factor receptor inhibitor 2 Other PubMed PubMed
CHEMBL3545319 JNJ-40346527 Macrophage colony stimulating factor receptor inhibitor 2 PubMed
CHEMBL3544959 ARRY-382 Macrophage colony stimulating factor receptor inhibitor 1 DOI Other
CHEMBL3544962 CT-1578 Macrophage colony stimulating factor receptor inhibitor 1 PubMed
CHEMBL3545079 PLX-5622 Macrophage colony stimulating factor receptor inhibitor 1 PubMed PubMed
CHEMBL3545381 PLX-7486 Macrophage colony stimulating factor receptor inhibitor 1 Other
More...

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000182578
Ensembl ENSG00000182578
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:1990682 (CSF1-CSF1R complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005011 (macrophage colony-stimulating factor receptor activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019903 (protein phosphatase binding)
GO:0019955 (cytokine binding)
GO:0042803 (protein homodimerization activity)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0002376 (immune system process)
GO:0006468 (protein phosphorylation)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007275 (multicellular organism development)
GO:0007411 (axon guidance)
GO:0007519 (skeletal muscle tissue development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0021772 (olfactory bulb development)
GO:0021879 (forebrain neuron differentiation)
GO:0030097 (hemopoiesis)
GO:0030224 (monocyte differentiation)
GO:0030225 (macrophage differentiation)
GO:0030316 (osteoclast differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0031529 (ruffle organization)
GO:0036006 (cellular response to macrophage colony-stimulating factor stimulus)
GO:0038145 (macrophage colony-stimulating factor signaling pathway)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0043066 (negative regulation of apoptotic process)
GO:0045087 (innate immune response)
GO:0045124 (regulation of bone resorption)
GO:0045217 (cell-cell junction maintenance)
GO:0045672 (positive regulation of osteoclast differentiation)
GO:0046488 (phosphatidylinositol metabolic process)
GO:0046777 (protein autophosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0060603 (mammary gland duct morphogenesis)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071345 (cellular response to cytokine stimulus)
GO:0071902 (positive regulation of protein serine/threonine kinase activity)
GO:0090197 (positive regulation of chemokine secretion)
GO:2000147 (positive regulation of cell motility)
GO:2000249 (regulation of actin cytoskeleton reorganization)
Wikipedia Colony_stimulating_factor_1_receptor

Target Cross References - Protein

canSAR P07333
CGD Leukoencephalopathy, diffuse hereditary, with spheroids
Human Protein Atlas ENSG00000182578
IntAct P07333
Guide to Pharmacology 1806
Open Targets ENSG00000182578
PharmGKB PA26936
Pharos P07333 (Tclin)
Reactome R-HSA-449147 (Signaling by Interleukins.)
UniProt B5A955 D3DQG2 P07333 Q6LDW5 Q6LDY4 Q86VW7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001824 (Tyr_kinase_rcpt_3_CS.)
IPR003598 (Ig_sub2.)
IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR013151 (Immunoglobulin.)
IPR013783 (Ig-like_fold.)
IPR016243 (Tyr_kinase_CSF1/PDGF_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR030658 (CSF-1_receptor.)
Pfam PF00047 (ig)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM
CREDO 2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM
spacer
spacer