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Target Report Card

Target Name and Classification

Target ID CHEMBL1841
Preferred Name Tyrosine-protein kinase FYN
Synonyms FYN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | Src-like kinase | Tyrosine-protein kinase Fyn | p59-Fyn
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase src family

Target Components

Component Description Relationship Accession
Tyrosine-protein kinase Fyn SINGLE PROTEIN P06241

Target Relations

ChEMBL ID Pref Name Target Type

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545133 JNJ-26483327 Tyrosine-protein kinase FYN inhibitor 1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000010810
Ensembl ENSG00000010810
GO Cellular Component GO:0005634 (nucleus)
GO:0005739 (mitochondrion)
GO:0005768 (endosome)
GO:0005829 (cytosol)
GO:0005884 (actin filament)
GO:0005886 (plasma membrane)
GO:0014069 (postsynaptic density)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0004713 (protein tyrosine kinase activity)
GO:0004715 (non-membrane spanning protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO:0046875 (ephrin receptor binding)
GO:0070851 (growth factor receptor binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0001764 (neuron migration)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0006468 (protein phosphorylation)
GO:0006816 (calcium ion transport)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007243 (intracellular protein kinase cascade)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007265 (Ras protein signal transduction)
GO:0007411 (axon guidance)
GO:0007596 (blood coagulation)
GO:0007612 (learning)
GO:0007631 (feeding behavior)
GO:0008286 (insulin receptor signaling pathway)
GO:0008360 (regulation of cell shape)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0010629 (negative regulation of gene expression)
GO:0010976 (positive regulation of neuron projection development)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016032 (viral process)
GO:0016032 (viral reproduction)
GO:0016477 (cell migration)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030154 (cell differentiation)
GO:0030168 (platelet activation)
GO:0030900 (forebrain development)
GO:0031295 (T cell costimulation)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0035556 (intracellular signal transduction)
GO:0036120 (cellular response to platelet-derived growth factor stimulus)
GO:0038083 (peptidyl-tyrosine autophosphorylation)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038096 (Fc-gamma receptor signaling pathway involved in phagocytosis)
GO:0042110 (T cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0042177 (negative regulation of protein catabolic process)
GO:0042493 (response to drug)
GO:0042523 (positive regulation of tyrosine phosphorylation of Stat5 protein)
GO:0042981 (regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0044419 (interspecies interaction between organisms)
GO:0045087 (innate immune response)
GO:0045471 (response to ethanol)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048813 (dendrite morphogenesis)
GO:0050690 (regulation of defense response to virus by virus)
GO:0050798 (activated T cell proliferation)
GO:0050852 (T cell receptor signaling pathway)
GO:0050900 (leukocyte migration)
GO:0050966 (detection of mechanical stimulus involved in sensory perception of pain)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia FYN

Target Cross References - Protein

canSAR P06241
Human Protein Atlas ENSG00000010810
IntAct P06241
PharmGKB PA28454
UniProt B5BU57 E1P557 P06241 Q16248 Q5R3A6 Q5R3A7 Q8N5D7

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000980 (SH2.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001452 (SH3_domain.)
IPR008266 (Tyr_kinase_AS.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00017 (SH2)
PF00018 (SH3_1)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1AVZ 1EFN 1FYN 1G83 1M27 1SHF 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P
CREDO 1AVZ 1EFN 1FYN 1G83 1M27 1SHF 2DQ7 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P