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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1835
Target Type SINGLE PROTEIN
Preferred Name Thromboxane-A synthase
Synonyms CYP5 | CYP5A1 | Cytochrome P450 5A1 | TBXAS1 | TXA synthase | TXS | Thromboxane-A synthase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > cytochrome p450 > cytochrome p450 family 5 > cytochrome p450 family 5a > cytochrome p450 5a1

Target Components

Component Description Relationship Accession
Thromboxane-A synthase SINGLE PROTEIN P24557

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000059377
Ensembl ENSG00000059377
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004497 (monooxygenase activity)
GO:0004796 (thromboxane-A synthase activity)
GO:0005506 (iron ion binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016853 (isomerase activity)
GO:0020037 (heme binding)
GO:0036134 (12-hydroxyheptadecatrienoic acid synthase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001516 (prostaglandin biosynthetic process)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006690 (icosanoid metabolic process)
GO:0006693 (prostaglandin metabolic process)
GO:0019371 (cyclooxygenase pathway)
GO:0055114 (oxidation-reduction process)
Wikipedia Thromboxane-A_synthase

Target Cross References - Protein

canSAR P24557
CGD Ghosal hematodiaphyseal syndrome
Human Protein Atlas ENSG00000059377
IntAct P24557
Guide to Pharmacology 1353
Open Targets ENSG00000059377
PharmGKB PA349
Reactome R-HSA-211979 (Eicosanoids.)
R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt B4DJG6 E7EMU9 E7EP08 E7ESB5 O14987 P24557 Q16843 Q16844 Q8IUN1 Q96CN2 Q9GZW4 Q9HD77 Q9HD78 Q9HD79 Q9HD80 Q9HD81 Q9HD82 Q9HD83 Q9HD84

Target Cross References - Domain

InterPro IPR001128 (Cyt_P450.)
IPR002401 (Cyt_P450_E_grp-I.)
IPR017972 (Cyt_P450_CS.)
Pfam PF00067 (p450)
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