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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1833
Target Type SINGLE PROTEIN
Preferred Name Serotonin 2b (5-HT2b) receptor
Synonyms 5-HT-2B | 5-HT2B | 5-hydroxytryptamine receptor 2B | HTR2B | Serotonin receptor 2B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > serotonin receptor

Target Components

Component Description Relationship Accession
5-hydroxytryptamine receptor 2B SINGLE PROTEIN P41595

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111466 Serotonin receptor (2b and 2c) SELECTIVITY GROUP
CHEMBL2095200 Serotonin 2 (5-HT2) receptor PROTEIN FAMILY
CHEMBL2096904 Serotonin (5-HT) receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200843 METHYLERGONOVINE MALEATE Serotonin 2b (5-HT2b) receptor partial agonist 4 PubMed
CHEMBL1200938 METHYSERGIDE MALEATE Serotonin 2b (5-HT2b) receptor antagonist 4 ISBN PubMed
CHEMBL2104991 VABICASERIN HYDROCHLORIDE Serotonin 2b (5-HT2b) receptor antagonist 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135914
Ensembl ENSG00000135914
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0045202 (synapse)
GO Molecular Function GO:0001965 (G-protein alpha-subunit binding)
GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004993 (G-protein coupled serotonin receptor activity)
GO:0005096 (GTPase activator activity)
GO:0008144 (drug binding)
GO:0051378 (serotonin binding)
GO Biological Process GO:0001755 (neural crest cell migration)
GO:0001819 (positive regulation of cytokine production)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002031 (G-protein coupled receptor internalization)
GO:0003007 (heart morphogenesis)
GO:0003300 (cardiac muscle hypertrophy)
GO:0006182 (cGMP biosynthetic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006939 (smooth muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0007205 (protein kinase C-activating G-protein coupled receptor signaling pathway)
GO:0007210 (serotonin receptor signaling pathway)
GO:0007507 (heart development)
GO:0007610 (behavior)
GO:0008284 (positive regulation of cell proliferation)
GO:0010507 (negative regulation of autophagy)
GO:0010513 (positive regulation of phosphatidylinositol biosynthetic process)
GO:0014033 (neural crest cell differentiation)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0014827 (intestine smooth muscle contraction)
GO:0016310 (phosphorylation)
GO:0019722 (calcium-mediated signaling)
GO:0034220 (ion transmembrane transport)
GO:0035733 (hepatic stellate cell activation)
GO:0042310 (vasoconstriction)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0043647 (inositol phosphate metabolic process)
GO:0048598 (embryonic morphogenesis)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050795 (regulation of behavior)
GO:0051000 (positive regulation of nitric-oxide synthase activity)
GO:0051209 (release of sequestered calcium ion into cytosol)
GO:0051781 (positive regulation of cell division)
GO:0060548 (negative regulation of cell death)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070528 (protein kinase C signaling)
GO:0071418 (cellular response to amine stimulus)
GO:0071502 (cellular response to temperature stimulus)
GO:1904015 (cellular response to serotonin)
Wikipedia 5-HT2B_receptor

Target Cross References - Protein

canSAR P41595
Human Protein Atlas ENSG00000135914
Guide to Pharmacology 7
Open Targets ENSG00000135914
PharmGKB PA29554
Pharos P41595 (Tclin)
Reactome R-HSA-390666 (Serotonin receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt B2R9D5 P41595 Q53TI1 Q62221 Q6P523

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000482 (5HT2B_rcpt.)
IPR002231 (5HT_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 4IB4 4NC3 5TVN
CREDO 4IB4 4NC3 5TVN
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