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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1832
Target Type SINGLE PROTEIN
Preferred Name Calcitonin receptor
Synonyms CALCR | CT-R | Calcitonin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family b g protein-coupled receptor > peptide receptor (family b gpcr) > calcitonin-like receptor > calcitonin receptor

Target Components

Component Description Relationship Accession
Calcitonin receptor SINGLE PROTEIN P30988

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2364173 Amylin receptor AMY2; CALCR/RAMP2 PROTEIN COMPLEX
CHEMBL2111190 Amylin receptor AMY3; CALCR/RAMP3 PROTEIN COMPLEX
CHEMBL2111189 Amylin receptor AMY1, CALCR/RAMP1 PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201661 CALCITONIN SALMON RECOMBINANT Calcitonin receptor agonist 4 FDA IUPHAR
CHEMBL1201445 CALCITONIN SALMON Calcitonin receptor agonist 4 FDA IUPHAR
CHEMBL1201614 CALCITONIN HUMAN Calcitonin receptor agonist 4 FDA IUPHAR
CHEMBL3989767 CALCITONIN Calcitonin receptor agonist 4 PubMed PubMed PubMed PubMed PubMed PubMed PubMed PubMed
CHEMBL3545415 SMC021 Calcitonin receptor agonist 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000004948
Ensembl ENSG00000004948
GO Cellular Component GO:0005622 (intracellular)
GO:0005623 (cell)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:1903440 (amylin receptor complex)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004948 (calcitonin receptor activity)
GO:0005515 (protein binding)
GO:0008565 (protein transporter activity)
GO:0032841 (calcitonin binding)
GO:0038023 (signaling receptor activity)
GO:0097643 (amylin receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007202 (activation of phospholipase C activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0010628 (positive regulation of gene expression)
GO:0010739 (positive regulation of protein kinase A signaling)
GO:0010942 (positive regulation of cell death)
GO:0015031 (protein transport)
GO:0030816 (positive regulation of cAMP metabolic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0045762 (positive regulation of adenylate cyclase activity)
GO:0051384 (response to glucocorticoid)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0072659 (protein localization to plasma membrane)
GO:0097647 (amylin receptor signaling pathway)
GO:1905665 (positive regulation of calcium ion import across plasma membrane)
Wikipedia Calcitonin_receptor

Target Cross References - Protein

canSAR P30988
Human Protein Atlas ENSG00000004948
IntAct P30988
Guide to Pharmacology 43
Open Targets ENSG00000004948
PharmGKB PA26032
Pharos P30988 (Tclin)
Reactome R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-419812 (Calcitonin-like ligand receptors.)
UniProt A4D1G6 F5H605 O14585 P30988 Q13941 Q5ZGL8 Q659U6 Q6DJU8 Q6T712

Target Cross References - Domain

InterPro IPR000832 (GPCR_2_secretin-like.)
IPR001688 (GPCR_2_calcitonin_rcpt.)
IPR001879 (GPCR_2_extracellular_dom.)
IPR003287 (GCPR_2_calcitonin_rcpt_fam.)
IPR017981 (GPCR_2-like.)
IPR017983 (GPCR_2_secretin-like_CS.)
IPR036445 (GPCR_2_extracell_dom_sf.)
Pfam PF00002 (7tm_2)
PF02793 (HRM)

Target Cross References - Structure

PDBe 5II0
CREDO 5II0
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