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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1829
Preferred Name Histone deacetylase 3
Synonyms HD3 | HDAC3 | Histone deacetylase 3 | RPD3-2 | SMAP45
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class i

Target Components

Component Description Relationship Accession
Histone deacetylase 3 SINGLE PROTEIN O15379

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3430896 Histone deacetylase 1/2/3/6 PROTEIN FAMILY
CHEMBL3038483 Histone deacetylase 1/3/5/8 PROTEIN FAMILY
CHEMBL3038484 Histone deacetylase 3/NCoR1 PROTEIN COMPLEX
CHEMBL3430897 Histone deacetylase 1/2/3 PROTEIN FAMILY
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY
CHEMBL2111363 Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL98 VORINOSTAT Histone deacetylase 3 inhibitor 4 DailyMed
CHEMBL272980 MOCETINOSTAT Histone deacetylase 3 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000171720
Ensembl ENSG00000171720
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0005876 (spindle microtubule)
GO:0005886 (plasma membrane)
GO:0017053 (transcriptional repressor complex)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0003714 (transcription corepressor activity)
GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0030332 (cyclin binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0042826 (histone deacetylase binding)
GO:0051059 (NF-kappaB binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0007623 (circadian rhythm)
GO:0010832 (negative regulation of myotube differentiation)
GO:0016575 (histone deacetylation)
GO:0019216 (regulation of lipid metabolic process)
GO:0031647 (regulation of protein stability)
GO:0032008 (positive regulation of TOR signaling)
GO:0043066 (negative regulation of apoptotic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046329 (negative regulation of JNK cascade)
GO:0051225 (spindle assembly)
GO:0070932 (histone H3 deacetylation)
GO:0071498 (cellular response to fluid shear stress)
GO:1903507 (negative regulation of nucleic acid-templated transcription)
Wikipedia HDAC3

Target Cross References - Protein

canSAR O15379
Human Protein Atlas ENSG00000171720
IntAct O15379
Guide to Pharmacology 2617
Open Targets ENSG00000171720
PharmGKB PA29228
Reactome R-HSA-1368071 (NR1D1 (REV-ERBA) represses gene expression.)
R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-193670 (p75NTR negatively regulates cell cycle via SC1.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214815 (HDACs deacetylate histones.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-390471 (Association of TriC/CCT with target proteins during biosynthesis.)
R-HSA-400206 (Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).)
R-HSA-400253 (Circadian Clock.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-8940973 (RUNX2 regulates osteoblast differentiation.)
R-HSA-8943724 (Regulation of PTEN gene transcription.)
UniProt D3DQE1 O15379 O43268 Q9UEI5 Q9UEV0

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR003084 (His_deacetylse_1.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)

Target Cross References - Structure

PDBe 4A69