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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1828
Target Type SINGLE PROTEIN
Preferred Name DNA polymerase alpha subunit
Synonyms DNA polymerase alpha catalytic subunit p180 | DNA polymerase alpha catalytic subunit | POLA | POLA1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > transferase

Target Components

Component Description Relationship Accession
DNA polymerase alpha catalytic subunit SINGLE PROTEIN P09884

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363042 DNA polymerase (alpha/delta/epsilon) PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101868
Ensembl ENSG00000101868
GO Cellular Component GO:0000785 (chromatin)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005654 (nucleoplasm)
GO:0005658 (alpha DNA polymerase:primase complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0016363 (nuclear matrix)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0001882 (nucleoside binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003887 (DNA-directed DNA polymerase activity)
GO:0003896 (DNA primase activity)
GO:0005515 (protein binding)
GO:0008408 (3'-5' exonuclease activity)
GO:0016740 (transferase activity)
GO:0016779 (nucleotidyltransferase activity)
GO:0019901 (protein kinase binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0051536 (iron-sulfur cluster binding)
GO:0051539 (4 iron, 4 sulfur cluster binding)
GO Biological Process GO:0000082 (G1/S transition of mitotic cell cycle)
GO:0000083 (regulation of transcription involved in G1/S transition of mitotic cell cycle)
GO:0000722 (telomere maintenance via recombination)
GO:0000731 (DNA synthesis involved in DNA repair)
GO:0006260 (DNA replication)
GO:0006269 (DNA replication, synthesis of RNA primer)
GO:0006270 (DNA replication initiation)
GO:0006271 (DNA strand elongation involved in DNA replication)
GO:0006272 (leading strand elongation)
GO:0006273 (lagging strand elongation)
GO:0006281 (DNA repair)
GO:0006303 (double-strand break repair via nonhomologous end joining)
GO:0008283 (cell proliferation)
GO:0016032 (viral process)
GO:0071897 (DNA biosynthetic process)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
Wikipedia Polymerase_(DNA_directed),_alpha_1

Target Cross References - Protein

canSAR P09884
Human Protein Atlas ENSG00000101868
IntAct P09884
Open Targets ENSG00000101868
PharmGKB PA162399856
Reactome R-HSA-113501 (Inhibition of replication initiation of damaged DNA by RB1/E2F1.)
R-HSA-113510 (E2F mediated regulation of DNA replication.)
R-HSA-174411 (Polymerase switching on the C-strand of the telomere.)
R-HSA-174430 (Telomere C-strand synthesis initiation.)
R-HSA-68952 (DNA replication initiation.)
R-HSA-68962 (Activation of the pre-replicative complex.)
R-HSA-69091 (Polymerase switching.)
R-HSA-69166 (Removal of the Flap Intermediate.)
R-HSA-69183 (Processive synthesis on the lagging strand.)
R-HSA-69205 (G1/S-Specific Transcription.)
UniProt P09884 Q86UQ7

Target Cross References - Domain

InterPro IPR006133 (DNA-dir_DNA_pol_B_exonuc.)
IPR006134 (DNA-dir_DNA_pol_B_multi_dom.)
IPR006172 (DNA-dir_DNA_pol_B.)
IPR012337 (RNaseH-like_dom.)
IPR015088 (Znf_DNA-dir_DNA_pol_B_alpha.)
IPR017964 (DNA-dir_DNA_pol_B_CS.)
IPR023211 (DNA_pol_palm_dom.)
IPR024647 (DNA_pol_a_cat_su_N.)
IPR029702 (POLA/Pol1.)
Pfam PF00136 (DNA_pol_B)
PF03104 (DNA_pol_B_exo1)
PF08996 (zf-DNA_Pol)
PF12254 (DNA_pol_alpha_N)

Target Cross References - Structure

PDBe 4Q5V 4QCL 4Y97 5EXR 5IUD
CREDO 4Q5V 4QCL 4Y97 5EXR 5IUD
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