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Target Report Card

Target Name and Classification

Target ID CHEMBL1825
Preferred Name TNF-alpha
Synonyms C-domain 1 | C-domain 2 | Cachectin | ICD1 | ICD2 | Intracellular domain 1 | Intracellular domain 2 | N-terminal fragment | NTF | TNF | TNF-a | TNF-alpha | TNFA | TNFSF2 | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Tumor necrosis factor SINGLE PROTEIN P01375

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201572 ETANERCEPT TNF-alpha inhibitor 4 DailyMed PubMed
CHEMBL1201580 ADALIMUMAB TNF-alpha inhibitor 4 DailyMed
CHEMBL1201581 INFLIXIMAB TNF-alpha inhibitor 4 DailyMed
CHEMBL1201831 CERTOLIZUMAB PEGOL TNF-alpha inhibitor 4 DailyMed
CHEMBL1201833 GOLIMUMAB TNF-alpha inhibitor 4 DailyMed
CHEMBL2107911 ONERCEPT TNF-alpha inhibitor 3 PubMed
CHEMBL2108208 LENERCEPT TNF-alpha inhibitor 3 PubMed
CHEMBL2108566 NERELIMOMAB TNF-alpha inhibitor 3 PubMed
CHEMBL1743054 OZORALIZUMAB TNF-alpha inhibitor 2 PubMed
CHEMBL1743057 PEGSUNERCEPT TNF-alpha inhibitor 2 PubMed
CHEMBL2108739 PLACULUMAB TNF-alpha inhibitor 2 PubMed
CHEMBL2109587 AZ9773 TNF-alpha inhibitor 2 PubMed
CHEMBL2108887 AFELIMOMAB TNF-alpha inhibitor 0 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204490 ENSG00000206439 ENSG00000223952 ENSG00000228321 ENSG00000228849 ENSG00000230108 ENSG00000232810
Ensembl ENSG00000204490 ENSG00000206439 ENSG00000223952 ENSG00000228321 ENSG00000228849 ENSG00000230108 ENSG00000232810
GO Cellular Component GO:0001891 (phagocytic cup)
GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0045121 (membrane raft)
GO:0055037 (recycling endosome)
GO Molecular Function GO:0002020 (protease binding)
GO:0005125 (cytokine activity)
GO:0005164 (tumor necrosis factor receptor binding)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO:0044212 (transcription regulatory region DNA binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000165 (MAPK cascade)
GO:0000185 (activation of MAPKKK activity)
GO:0000187 (activation of MAPK activity)
GO:0001819 (positive regulation of cytokine production)
GO:0001932 (regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001937 (negative regulation of endothelial cell proliferation)
GO:0002439 (chronic inflammatory response to antigenic stimulus)
GO:0002740 (negative regulation of cytokine secretion involved in immune response)
GO:0002876 (positive regulation of chronic inflammatory response to antigenic stimulus)
GO:0002925 (positive regulation of humoral immune response mediated by circulating immunoglobulin)
GO:0006006 (glucose metabolic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006952 (defense response)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0006959 (humoral immune response)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007254 (JNK cascade)
GO:0007275 (multicellular organism development)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0009615 (response to virus)
GO:0009651 (response to salt stress)
GO:0009887 (organ morphogenesis)
GO:0010033 (response to organic substance)
GO:0010469 (regulation of receptor activity)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010693 (negative regulation of alkaline phosphatase activity)
GO:0010803 (regulation of tumor necrosis factor-mediated signaling pathway)
GO:0010888 (negative regulation of lipid storage)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0030198 (extracellular matrix organization)
GO:0030316 (osteoclast differentiation)
GO:0030730 (sequestering of triglyceride)
GO:0030866 (cortical actin cytoskeleton organization)
GO:0031334 (positive regulation of protein complex assembly)
GO:0031622 (positive regulation of fever generation)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032722 (positive regulation of chemokine production)
GO:0032729 (positive regulation of interferon-gamma production)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032757 (positive regulation of interleukin-8 production)
GO:0032800 (receptor biosynthetic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034116 (positive regulation of heterotypic cell-cell adhesion)
GO:0035509 (negative regulation of myosin-light-chain-phosphatase activity)
GO:0042127 (regulation of cell proliferation)
GO:0042742 (defense response to bacterium)
GO:0043065 (positive regulation of apoptotic process)
GO:0043068 (positive regulation of programmed cell death)
GO:0043122 (regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043242 (negative regulation of protein complex disassembly)
GO:0043243 (positive regulation of protein complex disassembly)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043491 (protein kinase B signaling)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0045071 (negative regulation of viral genome replication)
GO:0045080 (positive regulation of chemokine biosynthetic process)
GO:0045123 (cellular extravasation)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045662 (negative regulation of myoblast differentiation)
GO:0045668 (negative regulation of osteoblast differentiation)
GO:0045670 (regulation of osteoclast differentiation)
GO:0045672 (positive regulation of osteoclast differentiation)
GO:0045732 (positive regulation of protein catabolic process)
GO:0045785 (positive regulation of cell adhesion)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045994 (positive regulation of translational initiation by iron)
GO:0046325 (negative regulation of glucose import)
GO:0046330 (positive regulation of JNK cascade)
GO:0048566 (embryonic digestive tract development)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050708 (regulation of protein secretion)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050727 (regulation of inflammatory response)
GO:0050766 (positive regulation of phagocytosis)
GO:0050796 (regulation of insulin secretion)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0050900 (leukocyte migration)
GO:0050901 (leukocyte tethering or rolling)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051023 (regulation of immunoglobulin secretion)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051222 (positive regulation of protein transport)
GO:0051384 (response to glucocorticoid)
GO:0051798 (positive regulation of hair follicle development)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060557 (positive regulation of vitamin D biosynthetic process)
GO:0060559 (positive regulation of calcidiol 1-monooxygenase activity)
GO:0060664 (epithelial cell proliferation involved in salivary gland morphogenesis)
GO:0060693 (regulation of branching involved in salivary gland morphogenesis)
GO:0061048 (negative regulation of branching involved in lung morphogenesis)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070886 (positive regulation of calcineurin-NFAT signaling cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071316 (cellular response to nicotine)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071550 (death-inducing signaling complex assembly)
GO:0071677 (positive regulation of mononuclear cell migration)
GO:0071803 (positive regulation of podosome assembly)
GO:0072577 (endothelial cell apoptotic process)
GO:0072659 (protein localization to plasma membrane)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097527 (necroptotic signaling pathway)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:1901671 (positive regulation of superoxide dismutase activity)
GO:1903140 (regulation of establishment of endothelial barrier)
GO:1903347 (negative regulation of bicellular tight junction assembly)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
GO:1904996 (positive regulation of leukocyte adhesion to vascular endothelial cell)
GO:1904999 (positive regulation of leukocyte adhesion to arterial endothelial cell)
GO:2000010 (positive regulation of protein localization to cell surface)
GO:2000304 (positive regulation of ceramide biosynthetic process)
GO:2000334 (positive regulation of blood microparticle formation)
GO:2000343 (positive regulation of chemokine (C-X-C motif) ligand 2 production)
GO:2000377 (regulation of reactive oxygen species metabolic process)
GO:2001240 (negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia Tumor_necrosis_factor-alpha

Target Cross References - Protein

canSAR P01375
Human Protein Atlas ENSG00000204490 ENSG00000206439 ENSG00000223952 ENSG00000228321 ENSG00000228849 ENSG00000230108 ENSG00000232810
IntAct P01375
MICAD NBK23500 (Tumor necrosis factor alpha)
Open Targets ENSG00000204490 ENSG00000206439 ENSG00000223952 ENSG00000228321 ENSG00000228849 ENSG00000230108 ENSG00000232810
PharmGKB PA435
Reactome R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-5357786 (TNFR1-induced proapoptotic signaling.)
R-HSA-5357905 (Regulation of TNFR1 signaling.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5626978 (TNFR1-mediated ceramide production.)
R-HSA-5668541 (TNFR2 non-canonical NF-kB pathway.)
R-HSA-6783783 (Interleukin-10 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-75893 (TNF signaling.)
UniProt O43647 P01375 Q9P1Q2 Q9UIV3

Target Cross References - Domain

InterPro IPR002959 (TNF_alpha.)
IPR006052 (TNF_dom.)
IPR006053 (TNF.)
IPR008983 (Tumour_necrosis_fac-like_dom.)
IPR021184 (TNF_CS.)
Pfam PF00229 (TNF)

Target Cross References - Structure

PDBe 1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 3WD5 4G3Y 4TSV 4TWT 4Y6O 5M2I 5M2J 5M2M 5MU8 5TSW 5UUI 5WUX