ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1825
Target Type SINGLE PROTEIN
Preferred Name TNF-alpha
Synonyms C-domain 1 | C-domain 2 | Cachectin | ICD1 | ICD2 | Intracellular domain 1 | Intracellular domain 2 | N-terminal fragment | NTF | TNF | TNF-a | TNF-alpha | TNFA | TNFSF2 | Tumor necrosis factor | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Tumor necrosis factor SINGLE PROTEIN P01375

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201580 ADALIMUMAB TNF-alpha inhibitor DailyMed
CHEMBL1201831 CERTOLIZUMAB PEGOL TNF-alpha inhibitor DailyMed
CHEMBL1201572 ETANERCEPT TNF-alpha inhibitor DailyMed PubMed
CHEMBL1201833 GOLIMUMAB TNF-alpha inhibitor DailyMed
CHEMBL1201581 INFLIXIMAB TNF-alpha inhibitor DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000204490 ENSG00000206439 ENSG00000223952 ENSG00000228321 ENSG00000228849 ENSG00000230108 ENSG00000232810
Ensembl ENSG00000204490 ENSG00000206439 ENSG00000223952 ENSG00000228321 ENSG00000228849 ENSG00000230108 ENSG00000232810
GO Cellular Component GO:0001891 (phagocytic cup)
GO:0005615 (extracellular space)
GO:0005887 (integral to plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0045121 (membrane raft)
GO:0055037 (recycling endosome)
GO Molecular Function GO:0002020 (protease binding)
GO:0005125 (cytokine activity)
GO:0005164 (tumor necrosis factor receptor binding)
GO:0010843 (promoter binding)
GO:0016563 (transcription activator activity)
GO:0016564 (transcription repressor activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0000185 (activation of MAPKKK activity)
GO:0000187 (activation of MAPK activity)
GO:0002439 (chronic inflammatory response to antigenic stimulus)
GO:0002740 (negative regulation of cytokine secretion involved in immune response)
GO:0006916 (anti-apoptosis)
GO:0006919 (activation of caspase activity)
GO:0006927 (transformed cell apoptosis)
GO:0008625 (induction of apoptosis via death domain receptors)
GO:0009615 (response to virus)
GO:0009651 (response to salt stress)
GO:0010888 (negative regulation of lipid storage)
GO:0030730 (sequestering of triglyceride)
GO:0031622 (positive regulation of fever generation)
GO:0032715 (negative regulation of interleukin-6 production)
GO:0032722 (positive regulation of chemokine production)
GO:0032800 (receptor biosynthetic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034116 (positive regulation of heterotypic cell-cell adhesion)
GO:0042346 (positive regulation of NF-kappaB import into nucleus)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0043243 (positive regulation of protein complex disassembly)
GO:0045071 (negative regulation of viral genome replication)
GO:0045080 (positive regulation of chemokine biosynthetic process)
GO:0045429 (positive regulation of nitric oxide biosynthetic process)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045672 (positive regulation of osteoclast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048566 (embryonic digestive tract development)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050715 (positive regulation of cytokine secretion)
GO:0050796 (regulation of insulin secretion)
GO:0050901 (leukocyte tethering or rolling)
GO:0050995 (negative regulation of lipid catabolic process)
GO:0051044 (positive regulation of membrane protein ectodomain proteolysis)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051384 (response to glucocorticoid stimulus)
GO:0051533 (positive regulation of NFAT protein import into nucleus)
GO:0060555 (induction of necroptosis by extracellular signals)
GO:0060557 (positive regulation of vitamin D biosynthetic process)
GO:0060559 (positive regulation of calcidiol 1-monooxygenase activity)
GO:0061048 (negative regulation of branching involved in lung morphogenesis)
GO:0070265 (necrotic cell death)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071316 (cellular response to nicotine)
GO:0071803 (positive regulation of podosome assembly)
Wikipedia Tumor_necrosis_factor-alpha

Target Cross References - Protein

canSAR P01375
Human Protein Atlas ENSG00000204490 ENSG00000206439 ENSG00000223952 ENSG00000228321 ENSG00000228849 ENSG00000230108 ENSG00000232810
IntAct P01375
Guide to Pharmacology 2635 (tumor necrosis factor)
MICAD NBK23500 (Tumor necrosis factor alpha)
PharmGKB PA435
Reactome REACT_578 (Apoptosis.)
TIMBAL TNFa
UniProt O43647 P01375 Q9P1Q2 Q9UIV3

Target Cross References - Domain

InterPro IPR002959 (TNF_alpha.)
IPR006052 (TNF_family.)
IPR006053 (TNF_a/b/c.)
IPR008983 (Tumour_necrosis_fac-like.)
IPR021184 (TNF_CS.)
Pfam PF00229 (TNF)

Target Cross References - Structure

PDBe 1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 4TSV 5TSW
CREDO 1A8M 1TNF 2AZ5 2E7A 2TUN 2ZJC 2ZPX 3ALQ 3IT8 3L9J 4TSV 5TSW
spacer
spacer