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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1822
Target Type SINGLE PROTEIN
Preferred Name Inosine-5'-monophosphate dehydrogenase 1
Synonyms IMP dehydrogenase 1 | IMPD 1 | IMPD1 | IMPDH 1 | IMPDH-I | IMPDH1 | Inosine-5'-monophosphate dehydrogenase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
Inosine-5'-monophosphate dehydrogenase 1 SINGLE PROTEIN P20839

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111369 Inosine-5'-monophosphate dehydrogenase (IMPDH) PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1643 RIBAVIRIN Inosine-5'-monophosphate dehydrogenase 1 inhibitor 4 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106348
Ensembl ENSG00000106348
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0030054 (cell junction)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003676 (nucleic acid binding)
GO:0003677 (DNA binding)
GO:0003723 (RNA binding)
GO:0003824 (catalytic activity)
GO:0003938 (IMP dehydrogenase activity)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006164 (purine nucleotide biosynthetic process)
GO:0006177 (GMP biosynthetic process)
GO:0009168 (purine ribonucleoside monophosphate biosynthetic process)
GO:0009409 (response to cold)
GO:0046651 (lymphocyte proliferation)
GO:0055114 (oxidation-reduction process)
GO:0060041 (retina development in camera-type eye)
Wikipedia IMPDH1

Target Cross References - Protein

canSAR P20839
CGD Retinitis pigmentosa 10; Leber congenital amaurosis 11
Human Protein Atlas ENSG00000106348
IntAct P20839
Guide to Pharmacology 2624
Open Targets ENSG00000106348
PharmGKB PA29862
Reactome R-HSA-73817 (Purine ribonucleoside monophosphate biosynthesis.)
UniProt A4D0Z6 A4D0Z7 A6NDW5 A6NNI6 B3KNP7 B3KVM8 B4DE09 C9JV30 J3KNX8 P20839 Q8N194 Q96NU2

Target Cross References - Domain

InterPro IPR000644 (CBS_dom.)
IPR001093 (IMP_DH_GMPRt.)
IPR005990 (IMP_DH.)
IPR013785 (Aldolase_TIM.)
IPR015875 (IMP_DH/GMP_Rdtase_CS.)
Pfam PF00478 (IMPDH)
PF00571 (CBS)

Target Cross References - Structure

PDBe 1JCN
CREDO 1JCN
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