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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1821
Target Type SINGLE PROTEIN
Preferred Name Muscarinic acetylcholine receptor M4
Synonyms CHRM4 | Muscarinic acetylcholine receptor M4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M4 SINGLE PROTEIN P08173

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094109 Muscarinic acetylcholine receptor PROTEIN FAMILY
CHEMBL2111445 Muscarinic acetylcholine receptor M2 and M4 SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180720
Ensembl ENSG00000180720
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0032279 (asymmetric synapse)
GO:0042383 (sarcolemma)
GO:0043025 (neuronal cell body)
GO:0043679 (axon terminus)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0008283 (cell proliferation)
GO:0010033 (response to organic substance)
GO:0040012 (regulation of locomotion)
GO:0043547 (positive regulation of GTPase activity)
Wikipedia Muscarinic_acetylcholine_receptor_M4

Target Cross References - Protein

canSAR P08173
Human Protein Atlas ENSG00000180720
Guide to Pharmacology 16
Open Targets ENSG00000180720
PharmGKB PA26485
Pharos P08173 (Tclin)
Reactome R-HSA-390648 (Muscarinic acetylcholine receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt B2RPP4 P08173 Q0VD60 Q4VBK7

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000995 (Musac_Ach_rcpt.)
IPR001432 (Musac_Ach_M4_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 5DSG
CREDO 5DSG
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