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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1821
Preferred Name Muscarinic acetylcholine receptor M4
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > monoamine receptor > acetylcholine receptor

Target Components

Component Description Relationship Accession
Muscarinic acetylcholine receptor M4 SINGLE PROTEIN P08173

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2094109 Muscarinic acetylcholine receptor PROTEIN FAMILY
CHEMBL2111445 Muscarinic acetylcholine receptor M2 and M4 SELECTIVITY GROUP

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180720
Ensembl ENSG00000180720
GO Cellular Component GO:0043025 (neuronal cell body)
GO:0005887 (integral component of plasma membrane)
GO:0042383 (sarcolemma)
GO:0045211 (postsynaptic membrane)
GO:0032279 (asymmetric synapse)
GO:0045202 (synapse)
GO:0043679 (axon terminus)
GO:0005737 (cytoplasm)
GO:0014069 (postsynaptic density)
GO:0005886 (plasma membrane)
GO:0030054 (cell junction)
GO Molecular Function GO:0016907 (G-protein coupled acetylcholine receptor activity)
GO:0005085 (guanyl-nucleotide exchange factor activity)
GO Biological Process GO:0007213 (G-protein coupled acetylcholine receptor signaling pathway)
GO:0007606 (sensory perception of chemical stimulus)
GO:0007165 (signal transduction)
GO:0007207 (phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway)
GO:0007197 (adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway)
GO:0007271 (synaptic transmission, cholinergic)
GO:0040012 (regulation of locomotion)
GO:0007166 (cell surface receptor signaling pathway)
GO:0008283 (cell proliferation)
GO:0010033 (response to organic substance)
Wikipedia Muscarinic_acetylcholine_receptor_M4

Target Cross References - Protein

canSAR P08173
Human Protein Atlas ENSG00000180720
Guide to Pharmacology 16 (M4)
PharmGKB PA26485
UniProt Q4VBK7 B2RPP4 P08173 Q0VD60

Target Cross References - Domain

InterPro IPR000995 (Musac_Ach_rcpt.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR001432 (Musac_Ach_M4_rcpt.)
IPR000276 (GPCR_Rhodpsn.)
Pfam PF00001 (7tm_1)