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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1817
Target Type SINGLE PROTEIN
Preferred Name Erythropoietin receptor
Synonyms EPO-R | EPOR | Erythropoietin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Erythropoietin receptor SINGLE PROTEIN P19235

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201565 EPOETIN ALFA Erythropoietin receptor agonist 4 DailyMed FDA
CHEMBL1201566 DARBEPOETIN ALFA Erythropoietin receptor agonist 4 DailyMed FDA PubMed
CHEMBL1963684 PEGINESATIDE ACETATE Erythropoietin receptor agonist 4 FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187266
Ensembl ENSG00000187266
GO Cellular Component GO:0005576 (extracellular region)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004888 (transmembrane signaling receptor activity)
GO:0004896 (cytokine receptor activity)
GO:0004900 (erythropoietin receptor activity)
GO:0005515 (protein binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007420 (brain development)
GO:0007507 (heart development)
GO:0008284 (positive regulation of cell proliferation)
GO:0010976 (positive regulation of neuron projection development)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0038162 (erythropoietin-mediated signaling pathway)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0046697 (decidualization)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:1903206 (negative regulation of hydrogen peroxide-induced cell death)
Wikipedia Erythropoietin_receptor

Target Cross References - Protein

canSAR P19235
CGD Erythrocytosis, familial, 1
Human Protein Atlas ENSG00000187266
IntAct P19235
Guide to Pharmacology 1718
Open Targets ENSG00000187266
PharmGKB PA27834
UniProt B2RCG4 P19235 Q15443 Q2M205

Target Cross References - Domain

InterPro IPR003528 (Long_hematopoietin_rcpt_CS.)
IPR003961 (FN3_dom.)
IPR009167 (Erythropoietin_rcpt.)
IPR013783 (Ig-like_fold.)
IPR015152 (Growth/epo_recpt_lig-bind.)
Pfam PF00041 (fn3)
PF09067 (EpoR_lig-bind)

Target Cross References - Structure

PDBe 1CN4 1EBA 1EBP 1EER 1ERN 2JIX 4Y5V 4Y5X 4Y5Y
CREDO 1CN4 1EBA 1EBP 1EER 1ERN 2JIX 4Y5V 4Y5X 4Y5Y
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