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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1817
Target Type SINGLE PROTEIN
Preferred Name Erythropoietin receptor
Synonyms EPO-R | EPOR | Erythropoietin receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Erythropoietin receptor SINGLE PROTEIN P19235

Approved Drugs

ChEMBL ID Name Mechanism of Action References
CHEMBL1201566 DARBEPOETIN ALFA Erythropoietin receptor agonist DailyMed PubMed
CHEMBL1201565 EPOETIN ALFA Erythropoietin receptor agonist DailyMed
CHEMBL1963684 PEGINESATIDE ACETATE Erythropoietin receptor agonist FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000187266
Ensembl ENSG00000187266
GO Cellular Component GO:0005576 (extracellular region)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004900 (erythropoietin receptor activity)
GO:0042802 (identical protein binding)
Wikipedia Erythropoietin_receptor

Target Cross References - Protein

canSAR P19235
CGD Erythrocytosis, familial, 1
Human Protein Atlas ENSG00000187266
IntAct P19235
Guide to Pharmacology 1718 (Eythropoietin receptor)
PharmGKB PA27834
UniProt B2RCG4 P19235 Q15443 Q2M205

Target Cross References - Domain

InterPro IPR003528 (Long_hematopoietin_rcpt_CS.)
IPR003961 (FN_III.)
IPR008957 (Fibronectin_III_dom.)
IPR009167 (Erythropoietin_rcpt.)
IPR013783 (Ig-like_fold.)
IPR015152 (Growth/epo_recpt_lig-bind.)
Pfam PF00041 (fn3)
PF09067 (EpoR_lig-bind)

Target Cross References - Structure

PDBe 1CN4 1EBA 1EBP 1EER 1ERN 2JIX
CREDO 1CN4 1EBA 1EBP 1EER 1ERN 2JIX
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