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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1812
Target Type SINGLE PROTEIN
Preferred Name Pancreatic lipase
Synonyms PL | PNLIP | PTL | Pancreatic lipase | Pancreatic triacylglycerol lipase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Pancreatic triacylglycerol lipase SINGLE PROTEIN P16233

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL175247 ORLISTAT Pancreatic lipase inhibitor 4 DailyMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000175535
Ensembl ENSG00000175535
GO Cellular Component GO:0005576 (extracellular region)
GO Molecular Function GO:0004806 (triglyceride lipase activity)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO:0052689 (carboxylic ester hydrolase activity)
GO Biological Process GO:0001523 (retinoid metabolic process)
GO:0006629 (lipid metabolic process)
GO:0016042 (lipid catabolic process)
GO:0030299 (intestinal cholesterol absorption)
GO:0044241 (lipid digestion)
GO:0061365 (positive regulation of triglyceride lipase activity)
Wikipedia Pancreatic_lipase

Target Cross References - Protein

canSAR P16233
Human Protein Atlas ENSG00000175535
IntAct P16233
Guide to Pharmacology 2590
Open Targets ENSG00000175535
PharmGKB PA33478
Reactome R-HSA-192456 (Digestion of dietary lipid.)
R-HSA-975634 (Retinoid metabolism and transport.)
UniProt P16233 Q5VSQ2

Target Cross References - Domain

InterPro IPR000734 (TAG_lipase.)
IPR001024 (PLAT/LH2_dom.)
IPR002331 (Lipase_panc.)
IPR013818 (Lipase/vitellogenin.)
IPR016272 (Lipase_LIPH.)
IPR029058 (AB_hydrolase.)
IPR033906 (Lipase_N.)
Pfam PF00151 (Lipase)
PF01477 (PLAT)

Target Cross References - Structure

PDBe 1LPA 1LPB 1N8S
CREDO 1LPA 1LPB 1N8S
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