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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1810
Target Type SINGLE PROTEIN
Preferred Name Thyrotropin-releasing hormone receptor
Synonyms TRH-R | TRHR | Thyroliberin receptor | Thyrotropin-releasing hormone receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > neuropeptide receptor

Target Components

Component Description Relationship Accession
Thyrotropin-releasing hormone receptor SINGLE PROTEIN P34981

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1472 PROTIRELIN Thyrotropin-releasing hormone receptor agonist 4 DailyMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000174417
Ensembl ENSG00000174417
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004997 (thyrotropin-releasing hormone receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
Wikipedia Thyrotropin-releasing_hormone_receptor

Target Cross References - Protein

canSAR P34981
CGD Thyrotropin-releasing hormone resistance, generalized
Human Protein Atlas ENSG00000174417
Guide to Pharmacology 363
Open Targets ENSG00000174417
PharmGKB PA36979
Pharos P34981 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-416476 (G alpha (q) signalling events.)
UniProt P34981 Q2M339

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR002120 (TRH_rcpt_1.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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