ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1804
Preferred Name Somatostatin receptor 2
Synonyms SRIF-1 | SS-2-R | SS2-R | SS2R | SSTR2 | Somatostatin receptor type 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > somatostatin receptor

Target Components

Component Description Relationship Accession
Somatostatin receptor type 2 SINGLE PROTEIN P30874

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2111436 Somatostatin receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201184 LANREOTIDE ACETATE Somatostatin receptor 2 agonist 4 DailyMed
CHEMBL3039588 PASIREOTIDE DIASPARTATE Somatostatin receptor 2 agonist 4 DailyMed PubMed PubMed
CHEMBL3545188 PASIREOTIDE PAMOATE Somatostatin receptor 2 agonist 4 DailyMed PubMed PubMed
CHEMBL2103975 VAPREOTIDE Somatostatin receptor 2 agonist 3 Other PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000180616
Ensembl ENSG00000180616
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043005 (neuron projection)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004994 (somatostatin receptor activity)
GO:0005515 (protein binding)
GO:0030165 (PDZ domain binding)
GO:0042923 (neuropeptide binding)
GO Biological Process GO:0006937 (regulation of muscle contraction)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007193 (adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway)
GO:0007218 (neuropeptide signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0007268 (chemical synaptic transmission)
GO:0007283 (spermatogenesis)
GO:0007584 (response to nutrient)
GO:0007586 (digestion)
GO:0008285 (negative regulation of cell proliferation)
GO:0021549 (cerebellum development)
GO:0030432 (peristalsis)
GO:0030900 (forebrain development)
GO:0038170 (somatostatin signaling pathway)
GO:0042594 (response to starvation)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0071392 (cellular response to estradiol stimulus)
Wikipedia Somatostatin_receptor_2

Target Cross References - Protein

canSAR P30874
Human Protein Atlas ENSG00000180616
IntAct P30874
Guide to Pharmacology 356
Open Targets ENSG00000180616
PharmGKB PA36155
Pharos P30874 (Tclin)
Reactome R-HSA-375276 (Peptide ligand-binding receptors.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt A8K3Y0 B2R9P7 P30874 Q4VBP0 Q96GE0 Q96TF2 Q9BWH1

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000586 (Somatstn_rcpt.)
IPR002074 (Somatstn_rcpt_2.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)