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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1803
Target Type SINGLE PROTEIN
Preferred Name Leukocyte adhesion glycoprotein LFA-1 alpha
Synonyms CD11 antigen-like family member A | CD11A | CD_antigen=CD11a | ITGAL | Integrin alpha-L | LFA-1A | Leukocyte adhesion glycoprotein LFA-1 alpha chain | Leukocyte function-associated molecule 1 alpha chain
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor
  • adhesion

Target Components

Component Description Relationship Accession
Integrin alpha-L SINGLE PROTEIN P20701

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096661 Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 PROTEIN COMPLEX
CHEMBL2364172 Integrin alpha-L/beta-2 (LFA-1) PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109177 ODULIMOMAB Leukocyte adhesion glycoprotein LFA-1 alpha inhibitor 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005844
Ensembl ENSG00000005844
GO Cellular Component GO:0005886 (plasma membrane)
GO:0008305 (integrin complex)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0034687 (integrin alphaL-beta2 complex)
GO:0035579 (specific granule membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0030369 (ICAM-3 receptor activity)
GO:0044877 (macromolecular complex binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO:0050839 (cell adhesion molecule binding)
GO Biological Process GO:0002291 (T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)
GO:0006909 (phagocytosis)
GO:0006954 (inflammatory response)
GO:0007155 (cell adhesion)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007165 (signal transduction)
GO:0007229 (integrin-mediated signaling pathway)
GO:0030198 (extracellular matrix organization)
GO:0043113 (receptor clustering)
GO:0043312 (neutrophil degranulation)
GO:0050776 (regulation of immune response)
GO:0050900 (leukocyte migration)
GO:0098609 (cell-cell adhesion)
Wikipedia CD11a

Target Cross References - Protein

canSAR P20701
Human Protein Atlas ENSG00000005844
IntAct P20701
Guide to Pharmacology 2451
Open Targets ENSG00000005844
PharmGKB PA29948
Reactome R-HSA-198933 (Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-216083 (Integrin cell surface interactions.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8949275 (RUNX3 Regulates Immune Response and Cell Migration.)
UniProt O43746 P20701 Q45H73 Q96HB1 Q9UBC8

Target Cross References - Domain

InterPro IPR000413 (Integrin_alpha.)
IPR002035 (VWF_A.)
IPR013517 (FG-GAP.)
IPR013519 (Int_alpha_beta-p.)
IPR013649 (Integrin_alpha-2.)
IPR018184 (Integrin_alpha_C_CS.)
IPR028994 (Integrin_alpha_N.)
IPR032695 (Integrin_dom_sf.)
IPR036465 (vWFA_dom_sf.)
Pfam PF00092 (VWA)
PF00357 (Integrin_alpha)
PF01839 (FG-GAP)
PF08441 (Integrin_alpha2)

Target Cross References - Structure

PDBe 1CQP 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 More...
CREDO 1CQP 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 More...
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