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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1801
Target Type SINGLE PROTEIN
Preferred Name Plasminogen
Synonyms Activation peptide | Angiostatin | PLG | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B | Plasminogen
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > protease > serine protease > serine protease pa clan > serine protease s1a subfamily

Target Components

Component Description Relationship Accession
Plasminogen SINGLE PROTEIN P00747

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL877 TRANEXAMIC ACID Plasminogen inhibitor 4 DailyMed
CHEMBL1046 AMINOCAPROIC ACID Plasminogen inhibitor 4 DailyMed
CHEMBL1201593 ALTEPLASE Plasminogen activator 4 DailyMed
CHEMBL1201420 UROKINASE Plasminogen activator 4 DailyMed
CHEMBL1201619 APROTININ Plasminogen inhibitor 4 DailyMed
CHEMBL2107885 RETEPLASE Plasminogen activator 4 DailyMed
CHEMBL2108147 STREPTOKINASE Plasminogen activator 4 PubMed PubMed PubMed
CHEMBL2108791 TENECTEPLASE Plasminogen activator 4 DailyMed Other
CHEMBL3707226 DEFIBROTIDE SODIUM Plasminogen activator 4 FDA PubMed
CHEMBL2109084 DESMOTEPLASE Plasminogen activator 3 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000122194
Ensembl ENSG00000122194
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0031093 (platelet alpha granule lumen)
GO:0031232 (extrinsic component of external side of plasma membrane)
GO:0070062 (extracellular exosome)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0004252 (serine-type endopeptidase activity)
GO:0005102 (receptor binding)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008236 (serine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO:0019904 (protein domain specific binding)
GO:0034185 (apolipoprotein binding)
GO Biological Process GO:0002576 (platelet degranulation)
GO:0006508 (proteolysis)
GO:0007596 (blood coagulation)
GO:0007599 (hemostasis)
GO:0008285 (negative regulation of cell proliferation)
GO:0010812 (negative regulation of cell-substrate adhesion)
GO:0022617 (extracellular matrix disassembly)
GO:0042730 (fibrinolysis)
GO:0044267 (cellular protein metabolic process)
GO:0048771 (tissue remodeling)
GO:0051918 (negative regulation of fibrinolysis)
GO:0051919 (positive regulation of fibrinolysis)
GO:2000048 (negative regulation of cell-cell adhesion mediated by cadherin)
Wikipedia Plasmin

Target Cross References - Protein

canSAR P00747
CGD Plasminogen deficiency, type I
Human Protein Atlas ENSG00000122194
IntAct P00747
Guide to Pharmacology 2394
Open Targets ENSG00000122194
PharmGKB PA33405
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1474228 (Degradation of the extracellular matrix.)
R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-186797 (Signaling by PDGF.)
R-HSA-381426 (Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).)
R-HSA-75205 (Dissolution of Fibrin Clot.)
UniProt P00747 Q15146 Q5TEH4 Q6PA00

Target Cross References - Domain

InterPro IPR000001 (Kringle.)
IPR001254 (Trypsin_dom.)
IPR001314 (Peptidase_S1A.)
IPR003609 (Pan_app.)
IPR009003 (Peptidase_S1_PA.)
IPR013806 (Kringle-like.)
IPR018056 (Kringle_CS.)
IPR018114 (TRYPSIN_HIS.)
IPR023317 (Pept_S1A_plasmin.)
IPR033116 (TRYPSIN_SER.)
Pfam PF00024 (PAN_1)
PF00051 (Kringle)
PF00089 (Trypsin)

Target Cross References - Structure

PDBe 1BML 1BUI 1CEA 1CEB 1DDJ 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2PK4 3UIR 4A5T 4CIK 4DCB 4DUR 4DUU More...
CREDO 1BML 1BUI 1CEA 1CEB 1DDJ 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2PK4 3UIR 4A5T 4CIK 4DCB 4DUR 4DUU More...
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