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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795197
Preferred Name Heat-stable enterotoxin receptor
Synonyms GC-C | GUC2C | GUCY2C | Guanylyl cyclase C | Heat-stable enterotoxin receptor | Intestinal guanylate cyclase | STA receptor | STAR | hSTAR
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > lyase > guanylate cyclase > receptor guanylate cyclase

Target Components

Component Description Relationship Accession
Heat-stable enterotoxin receptor SINGLE PROTEIN P25092

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3301675 LINACLOTIDE Heat-stable enterotoxin receptor agonist 4 Expert

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000070019
Ensembl ENSG00000070019
GO Cellular Component GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005886 (plasma membrane)
GO:0008074 (guanylate cyclase complex, soluble)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004016 (adenylate cyclase activity)
GO:0004383 (guanylate cyclase activity)
GO:0004672 (protein kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0005525 (GTP binding)
GO:0015643 (toxic substance binding)
GO:0016829 (lyase activity)
GO:0016849 (phosphorus-oxygen lyase activity)
GO Biological Process GO:0006182 (cGMP biosynthetic process)
GO:0006468 (protein phosphorylation)
GO:0007168 (receptor guanylyl cyclase signaling pathway)
GO:0009190 (cyclic nucleotide biosynthetic process)
GO:0009636 (response to toxic substance)
GO:0035556 (intracellular signal transduction)
GO:0042127 (regulation of cell proliferation)
Wikipedia Guanylate_cyclase_2C

Target Cross References - Protein

canSAR P25092
CGD Diarrhea 6; Meconium ileus
Human Protein Atlas ENSG00000070019
IntAct P25092
Guide to Pharmacology 1750
Open Targets ENSG00000070019
PharmGKB PA29069
Pharos P25092 (Tclin)
UniProt B2RMY6 P25092

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001054 (A/G_cyclase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR011009 (Kinase-like_dom.)
IPR018297 (A/G_cyclase_CS.)
IPR028082 (Peripla_BP_I.)
IPR029787 (Nucleotide_cyclase.)
Pfam PF00211 (Guanylate_cyc)
PF07714 (Pkinase_Tyr)