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Target Report Card

Target Name and Classification

Target ID CHEMBL1795188
Preferred Name Proton-coupled folate transporter
Synonyms G21 | HCP1 | Heme carrier protein 1 | PCFT | PCFT/HCP1 | Proton-coupled folate transporter | SLC46A1 | Solute carrier family 46 member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc46 family of folate transporters

Target Components

Component Description Relationship Accession
Proton-coupled folate transporter SINGLE PROTEIN Q96NT5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000076351
Ensembl ENSG00000076351
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031526 (brush border membrane)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005542 (folic acid binding)
GO:0008517 (folic acid transporter activity)
GO:0015078 (hydrogen ion transmembrane transporter activity)
GO:0015232 (heme transporter activity)
GO:0015350 (methotrexate transporter activity)
GO Biological Process GO:0006810 (transport)
GO:0006879 (cellular iron ion homeostasis)
GO:0015884 (folic acid transport)
GO:0015886 (heme transport)
GO:0046655 (folic acid metabolic process)
GO:0051958 (methotrexate transport)
GO:0055085 (transmembrane transport)
GO:0098829 (intestinal folate absorption)
GO:1902600 (hydrogen ion transmembrane transport)
GO:1904447 (folic acid import into cell)
Wikipedia SLC46A1

Target Cross References - Protein

canSAR Q96NT5
CGD Folate malabsorption, hereditary
Human Protein Atlas ENSG00000076351
IntAct Q96NT5
Guide to Pharmacology 1213
Open Targets ENSG00000076351
PharmGKB PA162403775
Reactome R-HSA-196757 (Metabolism of folate and pterines.)
R-HSA-917937 (Iron uptake and transport.)
UniProt Q1HE20 Q86T92 Q8TEG3 Q96FL0 Q96NT5

Target Cross References - Domain

InterPro IPR005829 (Sugar_transporter_CS.)
IPR011701 (MFS.)
IPR020846 (MFS_dom.)
Pfam PF07690 (MFS_1)