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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795184
Target Type SINGLE PROTEIN
Preferred Name Protein polybromo-1
Synonyms BAF180 | BAF180 | BRG1-associated factor 180 | PB1 | PBRM1 | Polybromo-1D | Protein polybromo-1 | hPB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > bromodomain

Target Components

Component Description Relationship Accession
Protein polybromo-1 SINGLE PROTEIN Q86U86

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163939
Ensembl ENSG00000163939
GO Cellular Component GO:0000228 (nuclear chromosome)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0090544 (BAF-type complex)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0005515 (protein binding)
GO Biological Process GO:0006338 (chromatin remodeling)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007067 (mitotic nuclear division)
GO:0008285 (negative regulation of cell proliferation)
GO:0016568 (chromatin modification)
Wikipedia PBRM1

Target Cross References - Protein

canSAR Q86U86
Human Protein Atlas ENSG00000163939
IntAct Q86U86
Guide to Pharmacology 2738
Open Targets ENSG00000163939
PharmGKB PA162398846
Reactome R-HSA-3214858 (RMTs methylate histone arginines.)
UniProt A1L381 A1L382 A4FUJ7 Q1RMD1 Q1RMD2 Q86U86 Q96MS2 Q9H2T3 Q9H2T4 Q9H2T5 Q9H301 Q9H314

Target Cross References - Domain

InterPro IPR001025 (BAH_dom.)
IPR001487 (Bromodomain.)
IPR009071 (HMG_box_dom.)
IPR018359 (Bromodomain_CS.)
Pfam PF00439 (Bromodomain)
PF00505 (HMG_box)
PF01426 (BAH)

Target Cross References - Structure

PDBe 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID
CREDO 3G0J 3HMF 3IU5 3IU6 3K2J 3LJW 3MB4 3TLP 4Q0N 4Q0O 4Y03 5E7D 5FH6 5FH7 5FH8 5HRV 5HRW 5HRX 5II1 5II2 5IID
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