ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1795178
Target Type SINGLE PROTEIN
Preferred Name Transforming growth factor beta-1
Synonyms LAP | Latency-associated peptide | TGF-beta-1 | TGFB | TGFB1 | Transforming growth factor beta-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Transforming growth factor beta-1 SINGLE PROTEIN P01137

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3988637 Transforming growth factor beta PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743022 FRESOLIMUMAB Transforming growth factor beta-1 inhibitor 2 PubMed
CHEMBL2108431 METELIMUMAB Transforming growth factor beta-1 inhibitor 2 PubMed
CHEMBL2109585 LY-2382770 Transforming growth factor beta-1 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105329
Ensembl ENSG00000105329
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO:0005902 (microvillus)
GO:0009986 (cell surface)
GO:0030141 (secretory granule)
GO:0030424 (axon)
GO:0031012 (extracellular matrix)
GO:0031093 (platelet alpha granule lumen)
GO:0043025 (neuronal cell body)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0003823 (antigen binding)
GO:0005114 (type II transforming growth factor beta receptor binding)
GO:0005125 (cytokine activity)
GO:0005160 (transforming growth factor beta receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0019899 (enzyme binding)
GO:0034713 (type I transforming growth factor beta receptor binding)
GO:0034714 (type III transforming growth factor beta receptor binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043539 (protein serine/threonine kinase activator activity)
GO:0046982 (protein heterodimerization activity)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000165 (MAPK cascade)
GO:0001570 (vasculogenesis)
GO:0001657 (ureteric bud development)
GO:0001666 (response to hypoxia)
GO:0001763 (morphogenesis of a branching structure)
GO:0001775 (cell activation)
GO:0001837 (epithelial to mesenchymal transition)
GO:0001843 (neural tube closure)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002028 (regulation of sodium ion transport)
GO:0002062 (chondrocyte differentiation)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0002248 (connective tissue replacement involved in inflammatory response wound healing)
GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)
GO:0002513 (tolerance induction to self antigen)
GO:0002576 (platelet degranulation)
GO:0003179 (heart valve morphogenesis)
GO:0006468 (protein phosphorylation)
GO:0006611 (protein export from nucleus)
GO:0006754 (ATP biosynthetic process)
GO:0006796 (phosphate-containing compound metabolic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006915 (apoptotic process)
GO:0006954 (inflammatory response)
GO:0007050 (cell cycle arrest)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007182 (common-partner SMAD protein phosphorylation)
GO:0007183 (SMAD protein complex assembly)
GO:0007219 (Notch signaling pathway)
GO:0007406 (negative regulation of neuroblast proliferation)
GO:0007435 (salivary gland morphogenesis)
GO:0007492 (endoderm development)
GO:0007507 (heart development)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008354 (germ cell migration)
GO:0009314 (response to radiation)
GO:0009611 (response to wounding)
GO:0009749 (response to glucose)
GO:0009817 (defense response to fungus, incompatible interaction)
GO:0010033 (response to organic substance)
GO:0010468 (regulation of gene expression)
GO:0010469 (regulation of receptor activity)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010716 (negative regulation of extracellular matrix disassembly)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0010742 (macrophage derived foam cell differentiation)
GO:0010763 (positive regulation of fibroblast migration)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0010936 (negative regulation of macrophage cytokine production)
GO:0014003 (oligodendrocyte development)
GO:0014070 (response to organic cyclic compound)
GO:0016202 (regulation of striated muscle tissue development)
GO:0016477 (cell migration)
GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
GO:0019049 (evasion or tolerance of host defenses by virus)
GO:0019221 (cytokine-mediated signaling pathway)
GO:0021915 (neural tube development)
GO:0022408 (negative regulation of cell-cell adhesion)
GO:0030214 (hyaluronan catabolic process)
GO:0030217 (T cell differentiation)
GO:0030279 (negative regulation of ossification)
GO:0030308 (negative regulation of cell growth)
GO:0030316 (osteoclast differentiation)
GO:0030334 (regulation of cell migration)
GO:0030335 (positive regulation of cell migration)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0030879 (mammary gland development)
GO:0031065 (positive regulation of histone deacetylation)
GO:0031100 (organ regeneration)
GO:0031293 (membrane protein intracellular domain proteolysis)
GO:0031334 (positive regulation of protein complex assembly)
GO:0031536 (positive regulation of exit from mitosis)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032355 (response to estradiol)
GO:0032570 (response to progesterone)
GO:0032667 (regulation of interleukin-23 production)
GO:0032700 (negative regulation of interleukin-17 production)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0032801 (receptor catabolic process)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0032943 (mononuclear cell proliferation)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033280 (response to vitamin D)
GO:0034616 (response to laminar fluid shear stress)
GO:0035066 (positive regulation of histone acetylation)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0035902 (response to immobilization stress)
GO:0042060 (wound healing)
GO:0042110 (T cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0042130 (negative regulation of T cell proliferation)
GO:0042306 (regulation of protein import into nucleus)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042482 (positive regulation of odontogenesis)
GO:0042493 (response to drug)
GO:0042552 (myelination)
GO:0042981 (regulation of apoptotic process)
GO:0043011 (myeloid dendritic cell differentiation)
GO:0043029 (T cell homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043117 (positive regulation of vascular permeability)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043491 (protein kinase B signaling)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0043537 (negative regulation of blood vessel endothelial cell migration)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0043932 (ossification involved in bone remodeling)
GO:0045066 (regulatory T cell differentiation)
GO:0045216 (cell-cell junction organization)
GO:0045589 (regulation of regulatory T cell differentiation)
GO:0045591 (positive regulation of regulatory T cell differentiation)
GO:0045596 (negative regulation of cell differentiation)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045662 (negative regulation of myoblast differentiation)
GO:0045786 (negative regulation of cell cycle)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046732 (active induction of host immune response by virus)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048298 (positive regulation of isotype switching to IgA isotypes)
GO:0048468 (cell development)
GO:0048535 (lymph node development)
GO:0048565 (digestive tract development)
GO:0048642 (negative regulation of skeletal muscle tissue development)
GO:0048839 (inner ear development)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0050714 (positive regulation of protein secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050765 (negative regulation of phagocytosis)
GO:0050777 (negative regulation of immune response)
GO:0050868 (negative regulation of T cell activation)
GO:0050900 (leukocyte migration)
GO:0050921 (positive regulation of chemotaxis)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051098 (regulation of binding)
GO:0051101 (regulation of DNA binding)
GO:0051152 (positive regulation of smooth muscle cell differentiation)
GO:0051280 (negative regulation of release of sequestered calcium ion into cytosol)
GO:0051781 (positive regulation of cell division)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055010 (ventricular cardiac muscle tissue morphogenesis)
GO:0060312 (regulation of blood vessel remodeling)
GO:0060325 (face morphogenesis)
GO:0060364 (frontal suture morphogenesis)
GO:0060389 (pathway-restricted SMAD protein phosphorylation)
GO:0060390 (regulation of SMAD protein import into nucleus)
GO:0060391 (positive regulation of SMAD protein import into nucleus)
GO:0060395 (SMAD protein signal transduction)
GO:0060744 (mammary gland branching involved in thelarche)
GO:0060751 (branch elongation involved in mammary gland duct branching)
GO:0060762 (regulation of branching involved in mammary gland duct morphogenesis)
GO:0060965 (negative regulation of gene silencing by miRNA)
GO:0061035 (regulation of cartilage development)
GO:0070306 (lens fiber cell differentiation)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070723 (response to cholesterol)
GO:0071158 (positive regulation of cell cycle arrest)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071479 (cellular response to ionizing radiation)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0071677 (positive regulation of mononuclear cell migration)
GO:0085029 (extracellular matrix assembly)
GO:0090190 (positive regulation of branching involved in ureteric bud morphogenesis)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097421 (liver regeneration)
GO:1900126 (negative regulation of hyaluronan biosynthetic process)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1901203 (positive regulation of extracellular matrix assembly)
GO:1901666 (positive regulation of NAD+ ADP-ribosyltransferase activity)
GO:1902074 (response to salt)
GO:1902893 (regulation of pri-miRNA transcription by RNA polymerase II)
GO:1902895 (positive regulation of pri-miRNA transcription from RNA polymerase II promoter)
GO:1903077 (negative regulation of protein localization to plasma membrane)
GO:1903799 (negative regulation of production of miRNAs involved in gene silencing by miRNA)
GO:1903800 (positive regulation of production of miRNAs involved in gene silencing by miRNA)
GO:1903911 (positive regulation of receptor clustering)
GO:1905005 (regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)
GO:1905313 (transforming growth factor beta receptor signaling pathway involved in heart development)
GO:1990314 (cellular response to insulin-like growth factor stimulus)
GO:1990402 (embryonic liver development)
GO:2000249 (regulation of actin cytoskeleton reorganization)
GO:2000679 (positive regulation of transcription regulatory region DNA binding)
GO:2000727 (positive regulation of cardiac muscle cell differentiation)
Wikipedia TGF_beta_1

Target Cross References - Protein

canSAR P01137
CGD Camurati-Engelmann disease
Human Protein Atlas ENSG00000105329
IntAct P01137
Open Targets ENSG00000105329
PharmGKB PA350
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-168277 (Influenza Virus Induced Apoptosis.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-2129379 (Molecules associated with elastic fibres.)
R-HSA-2173788 (Downregulation of TGF-beta receptor signaling.)
R-HSA-2173789 (TGF-beta receptor signaling activates SMADs.)
R-HSA-2173791 (TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-3304356 (SMAD2/3 Phosphorylation Motif Mutants in Cancer.)
R-HSA-3315487 (SMAD2/3 MH2 Domain Mutants in Cancer.)
R-HSA-3642279 (TGFBR2 MSI Frameshift Mutants in Cancer.)
R-HSA-3645790 (TGFBR2 Kinase Domain Mutants in Cancer.)
R-HSA-3656532 (TGFBR1 KD Mutants in Cancer.)
R-HSA-3656535 (TGFBR1 LBD Mutants in Cancer.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-5689603 (UCH proteinases.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-8941855 (RUNX3 regulates CDKN1A transcription.)
R-HSA-8941858 (Regulation of RUNX3 expression and activity.)
R-HSA-8951936 (RUNX3 regulates p14-ARF.)
UniProt A8K792 P01137 Q9UCG4

Target Cross References - Domain

InterPro IPR001111 (TGF-b_propeptide.)
IPR001839 (TGF-b_C.)
IPR003939 (TGFb1.)
IPR015615 (TGF-beta-rel.)
IPR016319 (TGF-beta.)
IPR017948 (TGFb_CS.)
IPR029034 (Cystine-knot_cytokine.)
Pfam PF00019 (TGF_beta)
PF00688 (TGFb_propeptide)

Target Cross References - Structure

PDBe 3KFD 4KV5 5FFO 5VQP
CREDO 3KFD 4KV5 5FFO 5VQP
spacer
spacer