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Target Report Card

Target Name and Classification

Target ID CHEMBL1795178
Preferred Name Transforming growth factor beta-1
Synonyms LAP | Latency-associated peptide | TGF-beta-1 | TGFB | TGFB1 | Transforming growth factor beta-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Transforming growth factor beta-1 SINGLE PROTEIN P01137

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1743022 FRESOLIMUMAB Transforming growth factor beta-1 inhibitor 2 PubMed
CHEMBL2108431 METELIMUMAB Transforming growth factor beta-1 inhibitor 2 PubMed
CHEMBL2109585 LY-2382770 Transforming growth factor beta-1 inhibitor 2 PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105329
Ensembl ENSG00000105329
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005796 (Golgi lumen)
GO:0005886 (plasma membrane)
GO:0005902 (microvillus)
GO:0009986 (cell surface)
GO:0030141 (secretory granule)
GO:0030424 (axon)
GO:0031012 (extracellular matrix)
GO:0031093 (platelet alpha granule lumen)
GO:0043025 (neuronal cell body)
GO:0072562 (blood microparticle)
GO Molecular Function GO:0001948 (glycoprotein binding)
GO:0003823 (antigen binding)
GO:0005114 (type II transforming growth factor beta receptor binding)
GO:0005125 (cytokine activity)
GO:0005160 (transforming growth factor beta receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0019899 (enzyme binding)
GO:0034713 (type I transforming growth factor beta receptor binding)
GO:0034714 (type III transforming growth factor beta receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0043539 (protein serine/threonine kinase activator activity)
GO:0046982 (protein heterodimerization activity)
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0000060 (protein import into nucleus, translocation)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000165 (MAPK cascade)
GO:0001657 (ureteric bud development)
GO:0001666 (response to hypoxia)
GO:0001763 (morphogenesis of a branching structure)
GO:0001775 (cell activation)
GO:0001837 (epithelial to mesenchymal transition)
GO:0001933 (negative regulation of protein phosphorylation)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0002028 (regulation of sodium ion transport)
GO:0002062 (chondrocyte differentiation)
GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0002248 (connective tissue replacement involved in inflammatory response wound healing)
GO:0002460 (adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)
GO:0002513 (tolerance induction to self antigen)
GO:0002576 (platelet degranulation)
GO:0006468 (protein phosphorylation)
GO:0006611 (protein export from nucleus)
GO:0006754 (ATP biosynthetic process)
GO:0006796 (phosphate-containing compound metabolic process)
GO:0006874 (cellular calcium ion homeostasis)
GO:0006954 (inflammatory response)
GO:0007050 (cell cycle arrest)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007182 (common-partner SMAD protein phosphorylation)
GO:0007183 (SMAD protein complex assembly)
GO:0007184 (SMAD protein import into nucleus)
GO:0007219 (Notch signaling pathway)
GO:0007406 (negative regulation of neuroblast proliferation)
GO:0007435 (salivary gland morphogenesis)
GO:0007492 (endoderm development)
GO:0007565 (female pregnancy)
GO:0007568 (aging)
GO:0008156 (negative regulation of DNA replication)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0008354 (germ cell migration)
GO:0009314 (response to radiation)
GO:0009611 (response to wounding)
GO:0009749 (response to glucose)
GO:0009817 (defense response to fungus, incompatible interaction)
GO:0010033 (response to organic substance)
GO:0010468 (regulation of gene expression)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010716 (negative regulation of extracellular matrix disassembly)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0010742 (macrophage derived foam cell differentiation)
GO:0010763 (positive regulation of fibroblast migration)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0010862 (positive regulation of pathway-restricted SMAD protein phosphorylation)
GO:0010936 (negative regulation of macrophage cytokine production)
GO:0014003 (oligodendrocyte development)
GO:0014070 (response to organic cyclic compound)
GO:0016049 (cell growth)
GO:0016202 (regulation of striated muscle tissue development)
GO:0016477 (cell migration)
GO:0017015 (regulation of transforming growth factor beta receptor signaling pathway)
GO:0019049 (evasion or tolerance of host defenses by virus)
GO:0022408 (negative regulation of cell-cell adhesion)
GO:0030214 (hyaluronan catabolic process)
GO:0030217 (T cell differentiation)
GO:0030279 (negative regulation of ossification)
GO:0030308 (negative regulation of cell growth)
GO:0030334 (regulation of cell migration)
GO:0030335 (positive regulation of cell migration)
GO:0030501 (positive regulation of bone mineralization)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0030879 (mammary gland development)
GO:0031065 (positive regulation of histone deacetylation)
GO:0031100 (organ regeneration)
GO:0031334 (positive regulation of protein complex assembly)
GO:0031536 (positive regulation of exit from mitosis)
GO:0031663 (lipopolysaccharide-mediated signaling pathway)
GO:0032270 (positive regulation of cellular protein metabolic process)
GO:0032355 (response to estradiol)
GO:0032570 (response to progesterone)
GO:0032667 (regulation of interleukin-23 production)
GO:0032700 (negative regulation of interleukin-17 production)
GO:0032740 (positive regulation of interleukin-17 production)
GO:0032801 (receptor catabolic process)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0032943 (mononuclear cell proliferation)
GO:0032967 (positive regulation of collagen biosynthetic process)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0033280 (response to vitamin D)
GO:0034616 (response to laminar fluid shear stress)
GO:0035066 (positive regulation of histone acetylation)
GO:0035307 (positive regulation of protein dephosphorylation)
GO:0040007 (growth)
GO:0042060 (wound healing)
GO:0042110 (T cell activation)
GO:0042127 (regulation of cell proliferation)
GO:0042130 (negative regulation of T cell proliferation)
GO:0042306 (regulation of protein import into nucleus)
GO:0042307 (positive regulation of protein import into nucleus)
GO:0042482 (positive regulation of odontogenesis)
GO:0042493 (response to drug)
GO:0042552 (myelination)
GO:0042981 (regulation of apoptotic process)
GO:0043011 (myeloid dendritic cell differentiation)
GO:0043029 (T cell homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043117 (positive regulation of vascular permeability)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043491 (protein kinase B signaling)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0043537 (negative regulation of blood vessel endothelial cell migration)
GO:0043552 (positive regulation of phosphatidylinositol 3-kinase activity)
GO:0043932 (ossification involved in bone remodeling)
GO:0045066 (regulatory T cell differentiation)
GO:0045216 (cell-cell junction organization)
GO:0045589 (regulation of regulatory T cell differentiation)
GO:0045591 (positive regulation of regulatory T cell differentiation)
GO:0045596 (negative regulation of cell differentiation)
GO:0045599 (negative regulation of fat cell differentiation)
GO:0045662 (negative regulation of myoblast differentiation)
GO:0045786 (negative regulation of cell cycle)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045930 (negative regulation of mitotic cell cycle)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046732 (active induction of host immune response by virus)
GO:0048146 (positive regulation of fibroblast proliferation)
GO:0048298 (positive regulation of isotype switching to IgA isotypes)
GO:0048535 (lymph node development)
GO:0048565 (digestive tract development)
GO:0048642 (negative regulation of skeletal muscle tissue development)
GO:0048839 (inner ear development)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050680 (negative regulation of epithelial cell proliferation)
GO:0050714 (positive regulation of protein secretion)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050765 (negative regulation of phagocytosis)
GO:0050777 (negative regulation of immune response)
GO:0050868 (negative regulation of T cell activation)
GO:0050921 (positive regulation of chemotaxis)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051098 (regulation of binding)
GO:0051101 (regulation of DNA binding)
GO:0051152 (positive regulation of smooth muscle cell differentiation)
GO:0051280 (negative regulation of release of sequestered calcium ion into cytosol)
GO:0051781 (positive regulation of cell division)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0060312 (regulation of blood vessel remodeling)
GO:0060325 (face morphogenesis)
GO:0060364 (frontal suture morphogenesis)
GO:0060389 (pathway-restricted SMAD protein phosphorylation)
GO:0060390 (regulation of SMAD protein import into nucleus)
GO:0060391 (positive regulation of SMAD protein import into nucleus)
GO:0060395 (SMAD protein signal transduction)
GO:0060744 (mammary gland branching involved in thelarche)
GO:0060751 (branch elongation involved in mammary gland duct branching)
GO:0060762 (regulation of branching involved in mammary gland duct morphogenesis)
GO:0060965 (negative regulation of gene silencing by miRNA)
GO:0061035 (regulation of cartilage development)
GO:0070306 (lens fiber cell differentiation)
GO:0070723 (response to cholesterol)
GO:0071158 (positive regulation of cell cycle arrest)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0085029 (extracellular matrix assembly)
GO:0090190 (positive regulation of branching involved in ureteric bud morphogenesis)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:1900126 (negative regulation of hyaluronan biosynthetic process)
GO:1900182 (positive regulation of protein localization to nucleus)
GO:1901203 (positive regulation of extracellular matrix assembly)
GO:1901666 (positive regulation of NAD+ ADP-ribosyltransferase activity)
GO:1903077 (negative regulation of protein localization to plasma membrane)
GO:1903799 (negative regulation of production of miRNAs involved in gene silencing by miRNA)
GO:1903911 (positive regulation of receptor clustering)
GO:1905005 (regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)
GO:2000249 (regulation of actin cytoskeleton reorganization)
GO:2000679 (positive regulation of transcription regulatory region DNA binding)
GO:2000727 (positive regulation of cardiac muscle cell differentiation)
Wikipedia TGF_beta_1

Target Cross References - Protein

canSAR P01137
CGD Camurati-Engelmann disease
Human Protein Atlas ENSG00000105329
IntAct P01137
Open Targets ENSG00000105329
PharmGKB PA350
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-168277 (Influenza Virus Induced Apoptosis.)
R-HSA-202733 (Cell surface interactions at the vascular wall.)
R-HSA-2129379 (Molecules associated with elastic fibres.)
R-HSA-2173788 (Downregulation of TGF-beta receptor signaling.)
R-HSA-2173789 (TGF-beta receptor signaling activates SMADs.)
R-HSA-2173791 (TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).)
R-HSA-3000170 (Syndecan interactions.)
R-HSA-3000178 (ECM proteoglycans.)
R-HSA-3304356 (SMAD2/3 Phosphorylation Motif Mutants in Cancer.)
R-HSA-3315487 (SMAD2/3 MH2 Domain Mutants in Cancer.)
R-HSA-3642279 (TGFBR2 MSI Frameshift Mutants in Cancer.)
R-HSA-3645790 (TGFBR2 Kinase Domain Mutants in Cancer.)
R-HSA-3656532 (TGFBR1 KD Mutants in Cancer.)
R-HSA-3656535 (TGFBR1 LBD Mutants in Cancer.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-5689603 (UCH proteinases.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
UniProt A8K792 P01137 Q9UCG4

Target Cross References - Domain

InterPro IPR001111 (TGF-b_propeptide.)
IPR001839 (TGF-b_C.)
IPR003939 (TGFb1.)
IPR015615 (TGF-beta-rel.)
IPR016319 (TGF-beta.)
IPR017948 (TGFb_CS.)
IPR029034 (Cystine-knot_cytokine.)
Pfam PF00019 (TGF_beta)
PF00688 (TGFb_propeptide)

Target Cross References - Structure