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Target Report Card

Target Name and Classification

Target ID CHEMBL1795166
Target Type SINGLE PROTEIN
Preferred Name Sterol regulatory element-binding protein 2
Synonyms BHLHD2 | Class D basic helix-loop-helix protein 2 | Processed sterol regulatory element-binding protein 2 | SREBF2 | SREBP-2 | SREBP2 | Sterol regulatory element-binding protein 2 | Sterol regulatory element-binding transcription factor 2 | bHLHd2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Sterol regulatory element-binding protein 2 SINGLE PROTEIN Q12772

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198911
Ensembl ENSG00000198911
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0012507 (ER to Golgi transport vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031410 (cytoplasmic vesicle)
GO:0032937 (SREBP-SCAP-Insig complex)
GO Molecular Function GO:0000247 (C-8 sterol isomerase activity)
GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046983 (protein dimerization activity)
GO:0070888 (E-box binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006629 (lipid metabolic process)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0009267 (cellular response to starvation)
GO:0010886 (positive regulation of cholesterol storage)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0055098 (response to low-density lipoprotein particle)
GO:0071499 (cellular response to laminar fluid shear stress)
GO:0072368 (regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter)
GO:0090370 (negative regulation of cholesterol efflux)
GO:1903146 (regulation of mitophagy)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
GO:2000188 (regulation of cholesterol homeostasis)
Wikipedia SREBF2

Target Cross References - Protein

canSAR Q12772
Human Protein Atlas ENSG00000198911
IntAct Q12772
Open Targets ENSG00000198911
PharmGKB PA336
Reactome R-HSA-1655829 (Regulation of cholesterol biosynthesis by SREBP (SREBF).)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
UniProt Q05BD5 Q12772 Q6GTH7 Q86V36 Q9UH04

Target Cross References - Domain

InterPro IPR011598 (bHLH_dom.)
Pfam PF00010 (HLH)

Target Cross References - Structure

PDBe 1UKL
CREDO 1UKL
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