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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795151
Target Type SINGLE PROTEIN
Preferred Name Bis(5'-adenosyl)-triphosphatase
Synonyms AP3A hydrolase | AP3Aase | Bis(5'-adenosyl)-triphosphatase | Diadenosine 5',5'''-P1,P3-triphosphate hydrolase | Dinucleosidetriphosphatase | FHIT | Fragile histidine triad protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Bis(5'-adenosyl)-triphosphatase SINGLE PROTEIN P49789

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000189283
Ensembl ENSG00000189283
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003824 (catalytic activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042802 (identical protein binding)
GO:0047710 (bis(5'-adenosyl)-triphosphatase activity)
GO Biological Process GO:0006163 (purine nucleotide metabolic process)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006915 (apoptotic process)
GO:0009117 (nucleotide metabolic process)
GO:0032435 (negative regulation of proteasomal ubiquitin-dependent protein catabolic process)
GO:0072332 (intrinsic apoptotic signaling pathway by p53 class mediator)
Wikipedia FHIT

Target Cross References - Protein

canSAR P49789
Human Protein Atlas ENSG00000189283
IntAct P49789
Open Targets ENSG00000189283
PharmGKB PA28140
UniProt A2IAS9 A2IAT0 A2IAT6 A8K1A9 P49789 Q45QG9 Q6IU12

Target Cross References - Domain

InterPro IPR001310 (Histidine_triad_HIT.)
IPR011146 (HIT-like.)
IPR019808 (Histidine_triad_CS.)
Pfam PF01230 (HIT)

Target Cross References - Structure

PDBe 1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
CREDO 1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
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