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Target Report Card

Target Name and Classification

Target ID CHEMBL1795123
Preferred Name Hsp90 co-chaperone Cdc37
Synonyms CDC37 | CDC37A | Hsp90 chaperone protein kinase-targeting subunit | Hsp90 co-chaperone Cdc37 | Hsp90 co-chaperone Cdc37, N-terminally processed | p50Cdc37
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Hsp90 co-chaperone Cdc37 SINGLE PROTEIN Q16543

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000105401
Ensembl ENSG00000105401
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO:1990565 (HSP90-CDC37 chaperone complex)
GO Molecular Function GO:0004713 (protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0019887 (protein kinase regulator activity)
GO:0019900 (kinase binding)
GO:0019901 (protein kinase binding)
GO:0031072 (heat shock protein binding)
GO:0051082 (unfolded protein binding)
GO:0051087 (chaperone binding)
GO:0051879 (Hsp90 protein binding)
GO Biological Process GO:0000079 (regulation of cyclin-dependent protein serine/threonine kinase activity)
GO:0006457 (protein folding)
GO:0006605 (protein targeting)
GO:0010608 (posttranscriptional regulation of gene expression)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0038128 (ERBB2 signaling pathway)
GO:0045859 (regulation of protein kinase activity)
GO:0050821 (protein stabilization)
GO:0060334 (regulation of interferon-gamma-mediated signaling pathway)
GO:0060338 (regulation of type I interferon-mediated signaling pathway)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
Wikipedia CDC37

Target Cross References - Protein

canSAR Q16543
Human Protein Atlas ENSG00000105401
IntAct Q16543
Open Targets ENSG00000105401
PharmGKB PA402
Reactome R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1236382 (Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.)
R-HSA-5637810 (Constitutive Signaling by EGFRvIII.)
R-HSA-8863795 (Downregulation of ERBB2 signaling.)
UniProt Q16543 Q53YA2

Target Cross References - Domain

InterPro IPR004918 (Cdc37.)
IPR013855 (Cdc37_N_dom.)
IPR013873 (Cdc37_C.)
IPR013874 (Cdc37_Hsp90-bd.)
Pfam PF03234 (CDC37_N)
PF08564 (CDC37_C)
PF08565 (CDC37_M)

Target Cross References - Structure

PDBe 1US7 2W0G