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Target Report Card

Target Name and Classification

Target ID CHEMBL1795118
Preferred Name Histone-lysine N-methyltransferase SUV39H1
Synonyms H3-K9-HMTase 1 | Histone H3-K9 methyltransferase 1 | Histone-lysine N-methyltransferase SUV39H1 | KMT1A | Lysine N-methyltransferase 1A | Position-effect variegation 3-9 homolog | SUV39H | SUV39H1 | Su(var)3-9 homolog 1 | Suppressor of variegation 3-9 homolog 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > methyl-lysine/arginine binding protein > chromodomain
  • epigenetic regulator > writer > protein methyltransferase

Target Components

Component Description Relationship Accession
Histone-lysine N-methyltransferase SUV39H1 SINGLE PROTEIN O43463

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101945
Ensembl ENSG00000101945
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000792 (heterochromatin)
GO:0000794 (condensed nuclear chromosome)
GO:0005634 (nucleus)
GO:0005652 (nuclear lamina)
GO:0005654 (nucleoplasm)
GO:0005677 (chromatin silencing complex)
GO:0005694 (chromosome)
GO:0033553 (rDNA heterochromatin)
GO Molecular Function GO:0000976 (transcription regulatory region sequence-specific DNA binding)
GO:0003682 (chromatin binding)
GO:0005515 (protein binding)
GO:0008168 (methyltransferase activity)
GO:0008270 (zinc ion binding)
GO:0008757 (S-adenosylmethionine-dependent methyltransferase activity)
GO:0016740 (transferase activity)
GO:0018024 (histone-lysine N-methyltransferase activity)
GO:0042054 (histone methyltransferase activity)
GO:0046872 (metal ion binding)
GO:0046974 (histone methyltransferase activity (H3-K9 specific))
GO:0047485 (protein N-terminus binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000183 (chromatin silencing at rDNA)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006364 (rRNA processing)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007049 (cell cycle)
GO:0016032 (viral process)
GO:0030154 (cell differentiation)
GO:0032259 (methylation)
GO:0034968 (histone lysine methylation)
GO:0036123 (histone H3-K9 dimethylation)
GO:0036124 (histone H3-K9 trimethylation)
GO:0042754 (negative regulation of circadian rhythm)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0048511 (rhythmic process)
GO:0071456 (cellular response to hypoxia)
Wikipedia SUV39H1

Target Cross References - Protein

canSAR O43463
Human Protein Atlas ENSG00000101945
IntAct O43463
Guide to Pharmacology 2715
Open Targets ENSG00000101945
PharmGKB PA36264
Reactome R-HSA-3214841 (PKMTs methylate histone lysines.)
R-HSA-427359 (SIRT1 negatively regulates rRNA expression.)
UniProt B2R6E8 B4DST0 O43463 Q53G60 Q6FHK6

Target Cross References - Domain

InterPro IPR000953 (Chromo/chromo_shadow_dom.)
IPR001214 (SET_dom.)
IPR003616 (Post-SET_dom.)
IPR007728 (Pre-SET_dom.)
IPR011381 (Histone_H3-K9_MeTrfase.)
IPR016197 (Chromo-like_dom_sf.)
IPR023779 (Chromodomain_CS.)
IPR023780 (Chromo_domain.)
Pfam PF00385 (Chromo)
PF00856 (SET)
PF05033 (Pre-SET)

Target Cross References - Structure