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Target Report Card

Target Name and Classification

Target ID CHEMBL1795116
Preferred Name Protein arginine N-methyltransferase 5
Synonyms 72 kDa ICln-binding protein | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | Protein arginine N-methyltransferase 5 | Protein arginine N-methyltransferase 5, N-terminally processed | SKB1 homolog | SKB1 | SKB1Hs | Shk1 kinase-binding protein 1 homolog
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > protein methyltransferase > protein arginine methyltransferase

Target Components

Component Description Relationship Accession
Protein arginine N-methyltransferase 5 SINGLE PROTEIN O14744

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100462
Ensembl ENSG00000100462
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005794 (Golgi apparatus)
GO:0005829 (cytosol)
GO:0034709 (methylosome)
GO:0035097 (histone methyltransferase complex)
GO:0043234 (protein complex)
GO Molecular Function GO:0001046 (core promoter sequence-specific DNA binding)
GO:0003714 (transcription corepressor activity)
GO:0005515 (protein binding)
GO:0008168 (methyltransferase activity)
GO:0008327 (methyl-CpG binding)
GO:0008469 (histone-arginine N-methyltransferase activity)
GO:0016274 (protein-arginine N-methyltransferase activity)
GO:0016740 (transferase activity)
GO:0032403 (protein complex binding)
GO:0035243 (protein-arginine omega-N symmetric methyltransferase activity)
GO:0043021 (ribonucleoprotein complex binding)
GO:0044020 (histone methyltransferase activity (H4-R3 specific))
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000387 (spliceosomal snRNP assembly)
GO:0006351 (transcription, DNA-templated)
GO:0006353 (DNA-templated transcription, termination)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006479 (protein methylation)
GO:0007088 (regulation of mitotic nuclear division)
GO:0008283 (cell proliferation)
GO:0016568 (chromatin modification)
GO:0018216 (peptidyl-arginine methylation)
GO:0019918 (peptidyl-arginine methylation, to symmetrical-dimethyl arginine)
GO:0032259 (methylation)
GO:0032922 (circadian regulation of gene expression)
GO:0035246 (peptidyl-arginine N-methylation)
GO:0042118 (endothelial cell activation)
GO:0043985 (histone H4-R3 methylation)
GO:0044030 (regulation of DNA methylation)
GO:0045596 (negative regulation of cell differentiation)
GO:0048511 (rhythmic process)
GO:0048714 (positive regulation of oligodendrocyte differentiation)
GO:0070372 (regulation of ERK1 and ERK2 cascade)
GO:0090161 (Golgi ribbon formation)
GO:0097421 (liver regeneration)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1903507 (negative regulation of nucleic acid-templated transcription)
GO:1904992 (positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway)
Wikipedia Protein_arginine_methyltransferase_5

Target Cross References - Protein

canSAR O14744
Human Protein Atlas ENSG00000100462
IntAct O14744
Guide to Pharmacology 1256
Open Targets ENSG00000100462
PharmGKB PA35794
Reactome R-HSA-191859 (snRNP Assembly.)
R-HSA-3214858 (RMTs methylate histone arginines.)
R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
UniProt A8MTP3 A8MZ91 B4DX49 B4DY30 B5BU10 D3DS33 E2QRE7 O14744 Q6IBR1 Q9UKH1

Target Cross References - Domain

InterPro IPR007857 (Arg_MeTrfase_PRMT5.)
IPR025799 (Arg_MeTrfase.)
IPR029063 (SAM-dependent_MTases.)
Pfam PF05185 (PRMT5)

Target Cross References - Structure

PDBe 4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5
CREDO 4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5