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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795114
Target Type SINGLE PROTEIN
Preferred Name CD209 antigen
Synonyms C-type lectin domain family 4 member L | CD209 antigen | CD209 | CD_antigen=CD209 | CLEC4L | DC-SIGN | DC-SIGN1 | Dendritic cell-specific ICAM-3-grabbing non-integrin 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • surface antigen

Target Components

Component Description Relationship Accession
CD209 antigen SINGLE PROTEIN Q9NNX6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000090659
Ensembl ENSG00000090659
GO Cellular Component GO:0005576 (extracellular region)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043657 (host cell)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0005515 (protein binding)
GO:0005537 (mannose binding)
GO:0030246 (carbohydrate binding)
GO:0042605 (peptide antigen binding)
GO:0046790 (virion binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002250 (adaptive immune response)
GO:0002376 (immune system process)
GO:0006897 (endocytosis)
GO:0007155 (cell adhesion)
GO:0007157 (heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)
GO:0007159 (leukocyte cell-cell adhesion)
GO:0009988 (cell-cell recognition)
GO:0016032 (viral process)
GO:0019048 (modulation by virus of host morphology or physiology)
GO:0019062 (virion attachment to host cell)
GO:0019079 (viral genome replication)
GO:0019882 (antigen processing and presentation)
GO:0035556 (intracellular signal transduction)
GO:0042102 (positive regulation of T cell proliferation)
GO:0042129 (regulation of T cell proliferation)
GO:0045087 (innate immune response)
GO:0046718 (viral entry into host cell)
GO:0046968 (peptide antigen transport)
GO:0075733 (intracellular transport of virus)
GO:0097323 (B cell adhesion)
Wikipedia DC-SIGN

Target Cross References - Protein

canSAR Q9NNX6
Human Protein Atlas ENSG00000090659
IntAct Q9NNX6
Open Targets ENSG00000090659
PharmGKB PA26199
Reactome R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-8851680 (Butyrophilin (BTN) family interactions.)
UniProt A8KAM4 A8MVQ9 G5E9C4 Q2TB19 Q96QP7 Q96QP8 Q96QP9 Q96QQ0 Q96QQ1 Q96QQ2 Q96QQ3 Q96QQ4 Q96QQ5 Q96QQ6 Q96QQ7 Q96QQ8 Q9NNX6

Target Cross References - Domain

InterPro IPR001304 (C-type_lectin-like.)
IPR016186 (C-type_lectin-like/link_sf.)
IPR016187 (CTDL_fold.)
IPR018378 (C-type_lectin_CS.)
IPR033989 (CD209-like_CTLD.)
Pfam PF00059 (Lectin_C)

Target Cross References - Structure

PDBe 1K9I 1SL4 1SL5 2IT5 2IT6 2XR5 2XR6
CREDO 1K9I 1SL4 1SL5 2IT5 2IT6 2XR5 2XR6
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