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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795113
Target Type SINGLE PROTEIN
Preferred Name Mannose-binding protein C
Synonyms COLEC1 | Collectin-1 | MBL | MBL2 | MBP-C | MBP1 | Mannan-binding protein | Mannose-binding lectin | Mannose-binding protein C
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Mannose-binding protein C SINGLE PROTEIN P11226

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005576 (extracellular region)
GO:0005581 (collagen trimer)
GO:0005615 (extracellular space)
GO:0009986 (cell surface)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005509 (calcium ion binding)
GO:0005537 (mannose binding)
GO:0048306 (calcium-dependent protein binding)
GO Biological Process GO:0001867 (complement activation, lectin pathway)
GO:0006953 (acute-phase response)
GO:0006956 (complement activation)
GO:0006958 (complement activation, classical pathway)
GO:0006979 (response to oxidative stress)
GO:0008228 (opsonization)
GO:0042742 (defense response to bacterium)
GO:0044130 (negative regulation of growth of symbiont in host)
GO:0045087 (innate immune response)
GO:0048525 (negative regulation of viral process)
GO:0050766 (positive regulation of phagocytosis)
GO:0050830 (defense response to Gram-positive bacterium)
GO:0051873 (killing by host of symbiont cells)
Wikipedia Mannan-binding_lectin

Target Cross References - Protein

canSAR P11226
CGD Mannose-binding protein deficiency
IntAct P11226
PharmGKB PA30665

Target Cross References - Domain

InterPro IPR001304 (C-type_lectin.)
IPR008160 (Collagen.)
IPR016186 (C-type_lectin-like.)
IPR016187 (C-type_lectin_fold.)
IPR018378 (C-type_lectin_CS.)
Pfam PF00059 (Lectin_C)
PF01391 (Collagen)

Target Cross References - Structure

PDBe 1HUP
CREDO 1HUP
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