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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795109
Target Type SINGLE PROTEIN
Preferred Name Ephrin-A2
Synonyms EFNA2 | EPH-related receptor tyrosine kinase ligand 6 | EPLG6 | Ephrin-A2 | HEK7 ligand | HEK7-L | LERK-6 | LERK6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Ephrin-A2 SINGLE PROTEIN O43921

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000099617
Ensembl ENSG00000099617
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031225 (anchored component of membrane)
GO:0031594 (neuromuscular junction)
GO:0043204 (perikaryon)
GO Molecular Function GO:0046875 (ephrin receptor binding)
GO Biological Process GO:0007267 (cell-cell signaling)
GO:0007411 (axon guidance)
GO:0021772 (olfactory bulb development)
GO:0030316 (osteoclast differentiation)
GO:0046849 (bone remodeling)
GO:0048013 (ephrin receptor signaling pathway)
Wikipedia EFNA2

Target Cross References - Protein

canSAR O43921
Human Protein Atlas ENSG00000099617
IntAct O43921
Open Targets ENSG00000099617
PharmGKB PA27657
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt O43921 O76020

Target Cross References - Domain

InterPro IPR001799 (Ephrin_RBD.)
IPR008972 (Cupredoxin.)
IPR019765 (Ephrin_CS.)
IPR031328 (Ephrin.)
IPR034252 (Ephrin-A_Ecto.)
Pfam PF00812 (Ephrin)

Target Cross References - Structure

PDBe 2WO3
CREDO 2WO3
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