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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795108
Preferred Name Elongation factor 2
Synonyms EEF2 | EF-2 | EF2 | Elongation factor 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • other cytosolic protein

Target Components

Component Description Relationship Accession
Elongation factor 2 SINGLE PROTEIN P13639

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201550 DENILEUKIN DIFTITOX Elongation factor 2 inhibitor 4 FDA PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000167658
Ensembl ENSG00000167658
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005844 (polysome)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016235 (aggresome)
GO:0034774 (secretory granule lumen)
GO:0042788 (polysomal ribosome)
GO:0045121 (membrane raft)
GO:0070062 (extracellular exosome)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002039 (p53 binding)
GO:0003723 (RNA binding)
GO:0003746 (translation elongation factor activity)
GO:0003924 (GTPase activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0008097 (5S rRNA binding)
GO:0019901 (protein kinase binding)
GO:0043022 (ribosome binding)
GO:0045296 (cadherin binding)
GO:0051015 (actin filament binding)
GO Biological Process GO:0002244 (hematopoietic progenitor cell differentiation)
GO:0002931 (response to ischemia)
GO:0003009 (skeletal muscle contraction)
GO:0006412 (translation)
GO:0006414 (translational elongation)
GO:0006479 (protein methylation)
GO:0007568 (aging)
GO:0014009 (glial cell proliferation)
GO:0017183 (peptidyl-diphthamide biosynthetic process from peptidyl-histidine)
GO:0032355 (response to estradiol)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035914 (skeletal muscle cell differentiation)
GO:0042493 (response to drug)
GO:0042542 (response to hydrogen peroxide)
GO:0043312 (neutrophil degranulation)
GO:0045471 (response to ethanol)
GO:0045727 (positive regulation of translation)
GO:0051593 (response to folic acid)
GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus)
GO:2000767 (positive regulation of cytoplasmic translation)
Wikipedia EEF2

Target Cross References - Protein

canSAR P13639
Human Protein Atlas ENSG00000167658
IntAct P13639
Open Targets ENSG00000167658
PharmGKB PA27650
Reactome R-HSA-156902 (Peptide chain elongation.)
R-HSA-5336415 (Uptake and function of diphtheria toxin.)
R-HSA-5358493 (Synthesis of diphthamide-EEF2.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-8876725 (Protein methylation.)
UniProt B2RMP5 D6W618 P13639 Q58J86

Target Cross References - Domain

InterPro IPR000640 (EFG_V-like.)
IPR000795 (TF_GTP-bd_dom.)
IPR004161 (EFTu-like_2.)
IPR005225 (Small_GTP-bd_dom.)
IPR005517 (Transl_elong_EFG/EF2_IV.)
IPR009000 (Transl_B-barrel_sf.)
IPR014721 (Ribosomal_S5_D2-typ_fold_subgr.)
IPR020568 (Ribosomal_S5_D2-typ_fold.)
IPR027417 (P-loop_NTPase.)
IPR031157 (G_TR_CS.)
IPR035647 (EFG_III/V.)
Pfam PF00009 (GTP_EFTU)
PF00679 (EFG_C)
PF03144 (GTP_EFTU_D2)
PF03764 (EFG_IV)