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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795103
Target Type SINGLE PROTEIN
Preferred Name Matrix metalloproteinase-25
Synonyms Leukolysin | MMP-25 | MMP20 | MMP25 | MMPL1 | MT-MMP 6 | MT6-MMP | MT6MMP | MT6MMP | MTMMP6 | Matrix metalloproteinase-25 | Membrane-type matrix metalloproteinase 6 | Membrane-type-6 matrix metalloproteinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Matrix metalloproteinase-25 SINGLE PROTEIN Q9NPA2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000008516
Ensembl ENSG00000008516
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031012 (extracellular matrix)
GO:0031225 (anchored component of membrane)
GO Molecular Function GO:0004222 (metalloendopeptidase activity)
GO:0005509 (calcium ion binding)
GO:0008233 (peptidase activity)
GO:0008237 (metallopeptidase activity)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006508 (proteolysis)
GO:0006954 (inflammatory response)
GO:0060022 (hard palate development)
Wikipedia MMP25

Target Cross References - Protein

canSAR Q9NPA2
Human Protein Atlas ENSG00000008516
IntAct Q9NPA2
Guide to Pharmacology 1647
Open Targets ENSG00000008516
PharmGKB PA30882
Reactome R-HSA-1592389 (Activation of Matrix Metalloproteinases.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt D3DUA8 Q9H3Q0 Q9NPA2

Target Cross References - Domain

InterPro IPR000585 (Hemopexin-like_dom.)
IPR001818 (Pept_M10_metallopeptidase.)
IPR002477 (Peptidoglycan-bd-like.)
IPR006026 (Peptidase_Metallo.)
IPR016293 (Pept_M10A_stromelysin-type.)
IPR018487 (Hemopexin-like_repeat.)
IPR021190 (Pept_M10A.)
IPR024079 (MetalloPept_cat_dom.)
IPR028733 (MMP25.)
IPR033739 (M10A_MMP.)
Pfam PF00045 (Hemopexin)
PF00413 (Peptidase_M10)
PF01471 (PG_binding_1)
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