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ChEMBL

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Target Report Card

Target Name and Classification

Target ID CHEMBL1795102
Target Type SINGLE PROTEIN
Preferred Name Rho-related GTP-binding protein RhoB
Synonyms ARH6 | ARHB | RHOB | Rho cDNA clone 6 | Rho-related GTP-binding protein RhoB | h6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Rho-related GTP-binding protein RhoB SINGLE PROTEIN P62745

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143878
Ensembl ENSG00000143878
GO Cellular Component GO:0005634 (nucleus)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005770 (late endosome)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0031902 (late endosome membrane)
GO:0032154 (cleavage furrow)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003924 (GTPase activity)
GO:0005515 (protein binding)
GO:0005525 (GTP binding)
GO:0019003 (GDP binding)
GO Biological Process GO:0000910 (cytokinesis)
GO:0001525 (angiogenesis)
GO:0006810 (transport)
GO:0006886 (intracellular protein transport)
GO:0006915 (apoptotic process)
GO:0007155 (cell adhesion)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007266 (Rho protein signal transduction)
GO:0007275 (multicellular organism development)
GO:0008333 (endosome to lysosome transport)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0015031 (protein transport)
GO:0030154 (cell differentiation)
GO:0030168 (platelet activation)
GO:0030334 (regulation of cell migration)
GO:0030336 (negative regulation of cell migration)
GO:0043065 (positive regulation of apoptotic process)
GO:0045766 (positive regulation of angiogenesis)
GO:0045786 (negative regulation of cell cycle)
GO:0051056 (regulation of small GTPase mediated signal transduction)
GO:0061154 (endothelial tube morphogenesis)
GO:0070301 (cellular response to hydrogen peroxide)
GO:0071479 (cellular response to ionizing radiation)
Wikipedia RHOB

Target Cross References - Protein

Human Protein Atlas ENSG00000143878
IntAct P62745
Open Targets ENSG00000143878
PharmGKB PA24950
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-194840 (Rho GTPase cycle.)
R-HSA-416482 (G alpha (12/13) signalling events.)
R-HSA-416572 (Sema4D induced cell migration and growth-cone collapse.)
R-HSA-5625740 (RHO GTPases activate PKNs.)
R-HSA-5625900 (RHO GTPases activate CIT.)
R-HSA-5627117 (RHO GTPases Activate ROCKs.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-5666185 (RHO GTPases Activate Rhotekin and Rhophilins.)
UniProt B2R692 P01121 P62745 Q5U0H6 Q7RTN5 Q7RTR9 Q9CUV7

Target Cross References - Domain

InterPro IPR001806 (Small_GTPase.)
IPR005225 (Small_GTP-bd_dom.)
IPR027417 (P-loop_NTPase.)
Pfam PF00071 (Ras)

Target Cross References - Structure

PDBe 2FV8
CREDO 2FV8
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