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Target Report Card

Target Name and Classification

Target ID CHEMBL1795094
Preferred Name Nuclear receptor subfamily 0 group B member 1
Synonyms AHC | DAX1 | DSS-AHC critical region on the X chromosome protein 1 | NR0B1 | Nuclear receptor DAX-1 | Nuclear receptor subfamily 0 group B member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 0 > nuclear hormone receptor subfamily 0 group b > nuclear hormone receptor subfamily 0 group b member 1

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 0 group B member 1 SINGLE PROTEIN P51843

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169297
Ensembl ENSG00000169297
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005815 (microtubule organizing center)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0042788 (polysomal ribosome)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0003677 (DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003714 (transcription corepressor activity)
GO:0003723 (RNA binding)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0019904 (protein domain specific binding)
GO:0032448 (DNA hairpin binding)
GO:0035258 (steroid hormone receptor binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0050682 (AF-2 domain binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006694 (steroid biosynthetic process)
GO:0007283 (spermatogenesis)
GO:0007530 (sex determination)
GO:0008104 (protein localization)
GO:0008406 (gonad development)
GO:0008584 (male gonad development)
GO:0021854 (hypothalamus development)
GO:0021983 (pituitary gland development)
GO:0030154 (cell differentiation)
GO:0030238 (male sex determination)
GO:0030325 (adrenal gland development)
GO:0030522 (intracellular receptor signaling pathway)
GO:0033144 (negative regulation of intracellular steroid hormone receptor signaling pathway)
GO:0033327 (Leydig cell differentiation)
GO:0035902 (response to immobilization stress)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0043433 (negative regulation of sequence-specific DNA binding transcription factor activity)
GO:0045596 (negative regulation of cell differentiation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0060008 (Sertoli cell differentiation)
Wikipedia DAX1

Target Cross References - Protein

canSAR P51843
CGD Adrenal hypoplasia, congenital; 46,XY sex reversal 2
Human Protein Atlas ENSG00000169297
IntAct P51843
Open Targets ENSG00000169297
PharmGKB PA31746
Pharos P51843 (Tbio)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt P51843 Q96F69

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR025900 (Nuclear_receptor_repeat.)
IPR033544 (NR0B1.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF14046 (NR_Repeat)

Target Cross References - Structure