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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1795093
Target Type SINGLE PROTEIN
Preferred Name Apoptotic protease-activating factor 1
Synonyms APAF-1 | APAF1 | Apoptotic protease-activating factor 1 | KIAA0413
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Apoptotic protease-activating factor 1 SINGLE PROTEIN O14727

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000120868
Ensembl ENSG00000120868
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0043293 (apoptosome)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008656 (cysteine-type endopeptidase activator activity involved in apoptotic process)
GO:0031072 (heat shock protein binding)
GO:0042802 (identical protein binding)
GO:0043531 (ADP binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001843 (neural tube closure)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007420 (brain development)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0008635 (activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)
GO:0010659 (cardiac muscle cell apoptotic process)
GO:0030154 (cell differentiation)
GO:0030900 (forebrain development)
GO:0034349 (glial cell apoptotic process)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0051260 (protein homooligomerization)
GO:0051402 (neuron apoptotic process)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0071560 (cellular response to transforming growth factor beta stimulus)
GO:0072432 (response to G1 DNA damage checkpoint signaling)
GO:0097190 (apoptotic signaling pathway)
GO:0097193 (intrinsic apoptotic signaling pathway)
GO:1902510 (regulation of apoptotic DNA fragmentation)
GO:2001235 (positive regulation of apoptotic signaling pathway)
Wikipedia APAF1

Target Cross References - Protein

canSAR O14727
Human Protein Atlas ENSG00000120868
IntAct O14727
Open Targets ENSG00000120868
PharmGKB PA24868
Reactome R-HSA-111458 (Formation of apoptosome.)
R-HSA-111459 (Activation of caspases through apoptosome-mediated cleavage.)
R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-6803207 (TP53 Regulates Transcription of Caspase Activators and Caspases.)
UniProt B2RMX8 O14727 O43297 Q7Z438 Q9BXZ6 Q9UBZ5 Q9UGN8 Q9UGN9 Q9UGP0 Q9UJ58 Q9UJ59 Q9UJ60 Q9UJ61 Q9UJ62 Q9UJ63 Q9UJ64 Q9UJ65 Q9UJ66 Q9UJ67 Q9UNC9

Target Cross References - Domain

InterPro IPR001315 (CARD.)
IPR001680 (WD40_repeat.)
IPR002182 (NB-ARC.)
IPR011029 (DEATH-like_dom.)
IPR015943 (WD40/YVTN_repeat-like_dom.)
IPR017251 (Apaf-1.)
IPR017986 (WD40_repeat_dom.)
IPR019775 (WD40_repeat_CS.)
IPR020472 (G-protein_beta_WD-40_rep.)
IPR027417 (P-loop_NTPase.)
Pfam PF00400 (WD40)
PF00619 (CARD)
PF00931 (NB-ARC)

Target Cross References - Structure

PDBe 1CY5 1Z6T 2P1H 2YGS 3YGS 4RHW
CREDO 1CY5 1Z6T 2P1H 2YGS 3YGS 4RHW
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