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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1793
Target Type SINGLE PROTEIN
Preferred Name Parathyroid hormone receptor
Synonyms PTH/PTHr receptor | PTH/PTHrP type I receptor | PTH1 receptor | PTH1R | PTHR | PTHR1 | Parathyroid hormone 1 receptor | Parathyroid hormone/parathyroid hormone-related peptide receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family b g protein-coupled receptor > peptide receptor (family b gpcr) > parathyroid hormone receptor > parathyroid hormone receptor

Target Components

Component Description Relationship Accession
Parathyroid hormone/parathyroid hormone-related peptide receptor SINGLE PROTEIN Q03431

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL525610 TERIPARATIDE Parathyroid hormone receptor agonist 4 DailyMed
CHEMBL1201549 TERIPARATIDE ACETATE Parathyroid hormone receptor agonist 4 DailyMed
CHEMBL2108078 PARATHYROID HORMONE Parathyroid hormone receptor agonist 4 FDA

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160801
Ensembl ENSG00000160801
GO Cellular Component GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0031526 (brush border membrane)
GO:0043235 (receptor complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004991 (parathyroid hormone receptor activity)
GO:0005515 (protein binding)
GO:0017046 (peptide hormone binding)
GO:0043621 (protein self-association)
GO Biological Process GO:0001501 (skeletal system development)
GO:0001503 (ossification)
GO:0002062 (chondrocyte differentiation)
GO:0002076 (osteoblast development)
GO:0006874 (cellular calcium ion homeostasis)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007187 (G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007189 (adenylate cyclase-activating G-protein coupled receptor signaling pathway)
GO:0007200 (phospholipase C-activating G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0030282 (bone mineralization)
GO:0045453 (bone resorption)
GO:0048469 (cell maturation)
GO:0060732 (positive regulation of inositol phosphate biosynthetic process)
Wikipedia Parathyroid_hormone_1_receptor

Target Cross References - Protein

canSAR Q03431
CGD Eiken syndrome; Chondrodysplasia, Blomstrand type; Metaphyseal chondrodysplasia, Murk Jansen type; Failure of tooth eruption, primary
Human Protein Atlas ENSG00000160801
IntAct Q03431
Guide to Pharmacology 331
Open Targets ENSG00000160801
PharmGKB PA33953
Pharos Q03431 (Tclin)
Reactome R-HSA-373080 (Class B/2 (Secretin family receptors).)
R-HSA-418555 (G alpha (s) signalling events.)
UniProt Q03431 Q2M1U3

Target Cross References - Domain

InterPro IPR000832 (GPCR_2_secretin-like.)
IPR001879 (GPCR_2_extracellular_dom.)
IPR002170 (GPCR_2_parathyroid_rcpt.)
IPR017981 (GPCR_2-like.)
IPR017983 (GPCR_2_secretin-like_CS.)
Pfam PF00002 (7tm_2)
PF02793 (HRM)

Target Cross References - Structure

PDBe 3C4M 3H3G 3L2J 4Z8J
CREDO 3C4M 3H3G 3L2J 4Z8J
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