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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1791
Target Type SINGLE PROTEIN
Preferred Name Amiloride-sensitive sodium channel alpha-subunit
Synonyms Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | ENaCA | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > epithelial sodium channel

Target Components

Component Description Relationship Accession
Amiloride-sensitive sodium channel subunit alpha SINGLE PROTEIN P37088

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2107836 Amiloride-sensitive sodium channel, ENaC PROTEIN COMPLEX

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL3545352 P-1037 Amiloride-sensitive sodium channel alpha-subunit blocker 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111319
Ensembl ENSG00000111319
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0005829 (cytosol)
GO:0016324 (apical plasma membrane)
GO:0070062 (extracellular exosome)
GO:0034706 (sodium channel complex)
GO:0009897 (external side of plasma membrane)
GO:0030864 (cortical actin cytoskeleton)
GO:0005886 (plasma membrane)
GO:0031514 (motile cilium)
GO:0060170 (ciliary membrane)
GO Molecular Function GO:0015280 (ligand-gated sodium channel activity)
GO:0050699 (WW domain binding)
GO Biological Process GO:0050909 (sensory perception of taste)
GO:0055078 (sodium ion homeostasis)
GO:0055085 (transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0050891 (multicellular organismal water homeostasis)
GO:0034220 (ion transmembrane transport)
GO:0050896 (response to stimulus)
Wikipedia SCNN1A

Target Cross References - Protein

canSAR P37088
CGD Pseudohypoaldosteronism, type I; Bronchiectasis with or without elevated sweat chloride 2
Human Protein Atlas ENSG00000111319
Guide to Pharmacology 738 (ENaC α)
PharmGKB PA305
UniProt C5HTZ0 P37088 A5X2U9 Q6GSQ6 Q9UM64 O43271

Target Cross References - Domain

InterPro IPR004724 (ENaC.)
IPR001873 (Na+channel_ASC.)
IPR020903 (Na+channel_ASC_CS.)
Pfam PF00858 (ASC)
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