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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1791
Preferred Name Amiloride-sensitive sodium channel alpha-subunit
Synonyms Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | ENaCA | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > epithelial sodium channel

Target Components

Component Description Relationship Accession
Amiloride-sensitive sodium channel subunit alpha SINGLE PROTEIN P37088

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2107836 Amiloride-sensitive sodium channel, ENaC PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111319
Ensembl ENSG00000111319
GO Cellular Component GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0050699 (WW domain binding)
GO Biological Process GO:0007588 (excretion)
GO:0050896 (response to stimulus)
GO:0050909 (sensory perception of taste)
Wikipedia SCNN1A

Target Cross References - Protein

canSAR P37088
CGD Pseudohypoaldosteronism, type I; Bronchiectasis with or without elevated sweat chloride 2
Human Protein Atlas ENSG00000111319
Guide to Pharmacology 738 (ENaC α)
PharmGKB PA305
UniProt A5X2U9 C5HTZ0 O43271 P37088 Q6GSQ6 Q9UM64

Target Cross References - Domain

InterPro IPR001873 (Na+channel_ASC.)
IPR004724 (EnaC.)
IPR020903 (Na+channel_ASC_CS.)
Pfam PF00858 (ASC)