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Target Report Card

Target Name and Classification

Target ID CHEMBL1791
Preferred Name Amiloride-sensitive sodium channel alpha-subunit
Synonyms Alpha-ENaC | Alpha-NaCH | Amiloride-sensitive sodium channel subunit alpha | ENaCA | Epithelial Na(+) channel subunit alpha | Nonvoltage-gated sodium channel 1 subunit alpha | SCNEA | SCNN1 | SCNN1A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > epithelial sodium channel

Target Components

Component Description Relationship Accession
Amiloride-sensitive sodium channel subunit alpha SINGLE PROTEIN P37088

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2107836 Amiloride-sensitive sodium channel, ENaC PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000111319
Ensembl ENSG00000111319
GO Cellular Component GO:0001669 (acrosomal vesicle)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005929 (cilium)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016324 (apical plasma membrane)
GO:0031514 (motile cilium)
GO:0034706 (sodium channel complex)
GO:0042995 (cell projection)
GO:0060170 (ciliary membrane)
GO:0070062 (extracellular exosome)
GO:0097228 (sperm principal piece)
GO Molecular Function GO:0005272 (sodium channel activity)
GO:0005515 (protein binding)
GO:0015280 (ligand-gated sodium channel activity)
GO:0050699 (WW domain binding)
GO Biological Process GO:0006811 (ion transport)
GO:0006814 (sodium ion transport)
GO:0034220 (ion transmembrane transport)
GO:0035725 (sodium ion transmembrane transport)
GO:0050891 (multicellular organismal water homeostasis)
GO:0050896 (response to stimulus)
GO:0050909 (sensory perception of taste)
GO:0055078 (sodium ion homeostasis)
Wikipedia SCNN1A

Target Cross References - Protein

canSAR P37088
CGD Pseudohypoaldosteronism, type I; Bronchiectasis with or without elevated sweat chloride 2
Human Protein Atlas ENSG00000111319
IntAct P37088
Guide to Pharmacology 738
Open Targets ENSG00000111319
PharmGKB PA305
Pharos P37088 (Tclin)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
UniProt A5X2U9 B4E2Q5 C5HTZ0 O43271 P37088 Q6GSQ6 Q9UM64

Target Cross References - Domain

InterPro IPR001873 (ENaC.)
IPR004724 (ENaC_chordates.)
IPR020903 (ENaC_CS.)
Pfam PF00858 (ASC)