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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1787
Target Type SINGLE PROTEIN
Preferred Name Steroid 5-alpha-reductase 1
Synonyms 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | S5AR 1 | SR type 1 | SRD5A1 | Steroid 5-alpha-reductase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > oxidoreductase

Target Components

Component Description Relationship Accession
3-oxo-5-alpha-steroid 4-dehydrogenase 1 SINGLE PROTEIN P18405

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363075 Steroid 5-alpha-reductase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145545
Ensembl ENSG00000145545
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031090 (organelle membrane)
GO:0043025 (neuronal cell body)
GO:0043209 (myelin sheath)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070852 (cell body fiber)
GO Molecular Function GO:0003865 (3-oxo-5-alpha-steroid 4-dehydrogenase activity)
GO:0009055 (electron carrier activity)
GO:0016491 (oxidoreductase activity)
GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
GO:0033218 (amide binding)
GO:0047751 (cholestenone 5-alpha-reductase activity)
GO:0070402 (NADPH binding)
GO Biological Process GO:0001655 (urogenital system development)
GO:0001889 (liver development)
GO:0006629 (lipid metabolic process)
GO:0006694 (steroid biosynthetic process)
GO:0006702 (androgen biosynthetic process)
GO:0007530 (sex determination)
GO:0007548 (sex differentiation)
GO:0008202 (steroid metabolic process)
GO:0008209 (androgen metabolic process)
GO:0008584 (male gonad development)
GO:0009267 (cellular response to starvation)
GO:0014070 (response to organic cyclic compound)
GO:0014850 (response to muscle activity)
GO:0016101 (diterpenoid metabolic process)
GO:0021510 (spinal cord development)
GO:0021766 (hippocampus development)
GO:0021794 (thalamus development)
GO:0021854 (hypothalamus development)
GO:0021983 (pituitary gland development)
GO:0021987 (cerebral cortex development)
GO:0030154 (cell differentiation)
GO:0030539 (male genitalia development)
GO:0030540 (female genitalia development)
GO:0032354 (response to follicle-stimulating hormone)
GO:0032355 (response to estradiol)
GO:0032869 (cellular response to insulin stimulus)
GO:0033574 (response to testosterone)
GO:0042428 (serotonin metabolic process)
GO:0042448 (progesterone metabolic process)
GO:0042493 (response to drug)
GO:0042747 (circadian sleep/wake cycle, REM sleep)
GO:0043627 (response to estrogen)
GO:0055114 (oxidation-reduction process)
GO:0060348 (bone development)
GO:0060416 (response to growth hormone)
GO:0060992 (response to fungicide)
GO:0071320 (cellular response to cAMP)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071392 (cellular response to estradiol stimulus)
GO:0071394 (cellular response to testosterone stimulus)
GO:0071407 (cellular response to organic cyclic compound)
GO:0071549 (cellular response to dexamethasone stimulus)
GO:0071872 (cellular response to epinephrine stimulus)
Wikipedia SRD5A1

Target Cross References - Protein

canSAR P18405
Human Protein Atlas ENSG00000145545
Open Targets ENSG00000145545
PharmGKB PA36112
Reactome R-HSA-193048 (Androgen biosynthesis.)
UniProt B2R7Q1 P18405 Q9UHY4 Q9UP36 Q9UP37

Target Cross References - Domain

InterPro IPR001104 (3-oxo-5_a-steroid_4-DH_C.)
IPR016636 (3-oxo-5-alpha-steroid_4-DH.)
Pfam PF02544 (Steroid_dh)
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