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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1786
Target Type SINGLE PROTEIN
Preferred Name Inositol-1(or 4)-monophosphatase 1
Synonyms D-galactose 1-phosphate phosphatase | IMP 1 | IMPA | IMPA1 | IMPase 1 | Inositol monophosphatase 1 | Inositol-1(or 4)-monophosphatase 1 | Lithium-sensitive myo-inositol monophosphatase A1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
Inositol monophosphatase 1 SINGLE PROTEIN P29218

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1200826 LITHIUM CARBONATE Inositol-1(or 4)-monophosphatase 1 inhibitor 4 DailyMed FDA PubMed
CHEMBL2103738 LITHIUM CITRATE HYDRATE Inositol-1(or 4)-monophosphatase 1 inhibitor 4 DailyMed FDA PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133731
Ensembl ENSG00000133731
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0005515 (protein binding)
GO:0008934 (inositol monophosphate 1-phosphatase activity)
GO:0016787 (hydrolase activity)
GO:0030145 (manganese ion binding)
GO:0031403 (lithium ion binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046872 (metal ion binding)
GO:0052832 (inositol monophosphate 3-phosphatase activity)
GO:0052833 (inositol monophosphate 4-phosphatase activity)
GO:0052834 (inositol monophosphate phosphatase activity)
GO Biological Process GO:0006020 (inositol metabolic process)
GO:0006021 (inositol biosynthetic process)
GO:0006661 (phosphatidylinositol biosynthetic process)
GO:0006796 (phosphate-containing compound metabolic process)
GO:0007165 (signal transduction)
GO:0043647 (inositol phosphate metabolic process)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0046855 (inositol phosphate dephosphorylation)
Wikipedia IMPA1

Target Cross References - Protein

canSAR P29218
Human Protein Atlas ENSG00000133731
IntAct P29218
Guide to Pharmacology 1463
Open Targets ENSG00000133731
PharmGKB PA29860
Reactome R-HSA-1855183 (Synthesis of IP2, IP, and Ins in the cytosol.)
UniProt B2R733 B4DLN3 B7Z6Q4 J3KQT7 P29218 Q9UK71

Target Cross References - Domain

InterPro IPR000760 (Inositol_monophosphatase-like.)
IPR020550 (Inositol_monophosphatase_CS.)
IPR020552 (Inositol_monoPase_Li-sen.)
IPR020583 (Inositol_monoP_metal-BS.)
IPR033942 (IMPase.)
Pfam PF00459 (Inositol_P)

Target Cross References - Structure

PDBe 1AWB 1IMA 1IMB 1IMC 1IMD 1IME 1IMF 2HHM 4AS4
CREDO 1AWB 1IMA 1IMB 1IMC 1IMD 1IME 1IMF 2HHM 4AS4
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