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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1785
Preferred Name Endothelin receptor ET-B
Synonyms EDNRB | ET-B | ET-BR | ETRB | Endothelin B receptor | Endothelin receptor non-selective type
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > short peptide receptor (family a gpcr) > endothelin receptor

Target Components

Component Description Relationship Accession
Endothelin B receptor SINGLE PROTEIN P24530

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2096678 Endothelin receptor, ET-A/ET-B PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136160
Ensembl ENSG00000136160
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0001600 (endothelin-B receptor activity)
GO:0017046 (peptide hormone binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0007194 (negative regulation of adenylate cyclase activity)
GO:0007200 (activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger)
GO:0014043 (negative regulation of neuron maturation)
GO:0014826 (vein smooth muscle contraction)
GO:0032269 (negative regulation of cellular protein metabolic process)
GO:0048246 (macrophage chemotaxis)
GO:0048484 (enteric nervous system development)
Wikipedia Endothelin_receptor_type_B

Target Cross References - Protein

canSAR P24530
CGD Waardenburg syndrome type 4A; ABCD syndrome
Human Protein Atlas ENSG00000136160
Guide to Pharmacology 220 (ETB)
PharmGKB PA27618
Reactome REACT_14797 (Signaling by GPCR.)
UniProt A2A2Z8 A8K3T4 O15343 P24530 Q59GB1 Q5W0G9 Q8NHM6 Q8NHM7 Q8NHM8 Q8NHM9 Q9UD23 Q9UQK3

Target Cross References - Domain

InterPro IPR000276 (7TM_GPCR_Rhodpsn.)
IPR000499 (Endthln_rcpt.)
IPR001112 (ETB_rcpt.)
IPR017452 (GPCR_Rhodpsn_supfam.)
Pfam PF00001 (7tm_1)