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Target Report Card

Target Name and Classification

Target ID CHEMBL1783
Target Type SINGLE PROTEIN
Preferred Name Vascular endothelial growth factor A
Synonyms VEGF | VEGF-A | VEGFA | VPF | Vascular endothelial growth factor A | Vascular permeability factor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Vascular endothelial growth factor A SINGLE PROTEIN P15692

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL1201421 PEGAPTANIB SODIUM Vascular endothelial growth factor A antagonist 4 DailyMed
CHEMBL1201583 BEVACIZUMAB Vascular endothelial growth factor A inhibitor 4 DailyMed PubMed
CHEMBL1201825 RANIBIZUMAB Vascular endothelial growth factor A inhibitor 4 DailyMed
CHEMBL1742982 AFLIBERCEPT Vascular endothelial growth factor A inhibitor 4 DailyMed DailyMed
CHEMBL1615835 MUPARFOSTAT Vascular endothelial growth factor A inhibitor 3 PubMed
CHEMBL2108313 CONBERCEPT Vascular endothelial growth factor A inhibitor 3 PubMed PubMed PubMed PubMed
CHEMBL3707253 BEVACIZUMAB 111IN Vascular endothelial growth factor A binding agent 0 PubMed PubMed
CHEMBL3707357 BROLUCIZUMAB Vascular endothelial growth factor A inhibitor 0 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000112715
Ensembl ENSG00000112715
GO Cellular Component GO:0005576 (extracellular region)
GO:0005578 (proteinaceous extracellular matrix)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0030141 (secretory granule)
GO:0031093 (platelet alpha granule lumen)
GO Molecular Function GO:0001968 (fibronectin binding)
GO:0005125 (cytokine activity)
GO:0005161 (platelet-derived growth factor receptor binding)
GO:0005172 (vascular endothelial growth factor receptor binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0008201 (heparin binding)
GO:0038191 (neuropilin binding)
GO:0042056 (chemoattractant activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043183 (vascular endothelial growth factor receptor 1 binding)
GO:0043184 (vascular endothelial growth factor receptor 2 binding)
GO:0046982 (protein heterodimerization activity)
GO:0048018 (receptor agonist activity)
GO:0050840 (extracellular matrix binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001525 (angiogenesis)
GO:0001541 (ovarian follicle development)
GO:0001569 (patterning of blood vessels)
GO:0001570 (vasculogenesis)
GO:0001666 (response to hypoxia)
GO:0001701 (in utero embryonic development)
GO:0001822 (kidney development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0002042 (cell migration involved in sprouting angiogenesis)
GO:0002052 (positive regulation of neuroblast proliferation)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002092 (positive regulation of receptor internalization)
GO:0002575 (basophil chemotaxis)
GO:0002576 (platelet degranulation)
GO:0002687 (positive regulation of leukocyte migration)
GO:0003007 (heart morphogenesis)
GO:0003151 (outflow tract morphogenesis)
GO:0003169 (coronary vein morphogenesis)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007498 (mesoderm development)
GO:0007595 (lactation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008360 (regulation of cell shape)
GO:0010595 (positive regulation of endothelial cell migration)
GO:0010628 (positive regulation of gene expression)
GO:0030154 (cell differentiation)
GO:0030224 (monocyte differentiation)
GO:0030225 (macrophage differentiation)
GO:0030324 (lung development)
GO:0030335 (positive regulation of cell migration)
GO:0030823 (regulation of cGMP metabolic process)
GO:0030855 (epithelial cell differentiation)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0031077 (post-embryonic camera-type eye development)
GO:0031334 (positive regulation of protein complex assembly)
GO:0031954 (positive regulation of protein autophosphorylation)
GO:0032147 (activation of protein kinase activity)
GO:0032793 (positive regulation of CREB transcription factor activity)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035148 (tube formation)
GO:0035767 (endothelial cell chemotaxis)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0036303 (lymph vessel morphogenesis)
GO:0038033 (positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)
GO:0038084 (vascular endothelial growth factor signaling pathway)
GO:0038091 (positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)
GO:0038190 (VEGF-activated neuropilin signaling pathway)
GO:0040007 (growth)
GO:0042462 (eye photoreceptor cell development)
GO:0042517 (positive regulation of tyrosine phosphorylation of Stat3 protein)
GO:0043066 (negative regulation of apoptotic process)
GO:0043117 (positive regulation of vascular permeability)
GO:0043129 (surfactant homeostasis)
GO:0043154 (negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043536 (positive regulation of blood vessel endothelial cell migration)
GO:0045766 (positive regulation of angiogenesis)
GO:0045785 (positive regulation of cell adhesion)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048469 (cell maturation)
GO:0048593 (camera-type eye morphogenesis)
GO:0048739 (cardiac muscle fiber development)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0048842 (positive regulation of axon extension involved in axon guidance)
GO:0048844 (artery morphogenesis)
GO:0050679 (positive regulation of epithelial cell proliferation)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0050918 (positive chemotaxis)
GO:0050927 (positive regulation of positive chemotaxis)
GO:0050930 (induction of positive chemotaxis)
GO:0051272 (positive regulation of cellular component movement)
GO:0051781 (positive regulation of cell division)
GO:0051894 (positive regulation of focal adhesion assembly)
GO:0060319 (primitive erythrocyte differentiation)
GO:0060749 (mammary gland alveolus development)
GO:0060754 (positive regulation of mast cell chemotaxis)
GO:0060948 (cardiac vascular smooth muscle cell development)
GO:0060982 (coronary artery morphogenesis)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0061419 (positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071456 (cellular response to hypoxia)
GO:0071542 (dopaminergic neuron differentiation)
GO:0071679 (commissural neuron axon guidance)
GO:0090037 (positive regulation of protein kinase C signaling)
GO:0090050 (positive regulation of cell migration involved in sprouting angiogenesis)
GO:0090190 (positive regulation of branching involved in ureteric bud morphogenesis)
GO:0090259 (regulation of retinal ganglion cell axon guidance)
GO:1900086 (positive regulation of peptidyl-tyrosine autophosphorylation)
GO:1900745 (positive regulation of p38MAPK cascade)
GO:1901727 (positive regulation of histone deacetylase activity)
GO:1902336 (positive regulation of retinal ganglion cell axon guidance)
GO:1902966 (positive regulation of protein localization to early endosome)
GO:1903572 (positive regulation of protein kinase D signaling)
Wikipedia Vascular_endothelial_growth_factor_A

Target Cross References - Protein

canSAR P15692
Human Protein Atlas ENSG00000112715
IntAct P15692
Guide to Pharmacology 2644
Open Targets ENSG00000112715
PharmGKB PA37302
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-194313 (VEGF ligand-receptor interactions.)
R-HSA-195399 (VEGF binds to VEGFR leading to receptor dimerization.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-5218921 (VEGFR2 mediated cell proliferation.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-8866910 (TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.)
TIMBAL Neuropilin-1
UniProt B5BU86 H0Y2S8 H0Y407 H0Y414 H0Y462 H0Y8N2 H3BLW7 O60720 O75875 P15692 Q074Z4 Q16889 Q5UB46 Q6P0P5 Q96KJ0 Q96L82 Q96NW5 Q9H1W8 Q9H1W9 Q9UH58 Q9UL23

Target Cross References - Domain

InterPro IPR000072 (PDGF/VEGF_dom.)
IPR023581 (PD_growth_factor_CS.)
IPR027928 (VEGF_C.)
IPR029034 (Cystine-knot_cytokine.)
Pfam PF00341 (PDGF)
PF14554 (VEGF_C)

Target Cross References - Structure

PDBe 1BJ1 1CZ8 1FLT 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VPF 1VPP 2FJG 2FJH 2QR0 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS More...
CREDO 1BJ1 1CZ8 1FLT 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VPF 1VPP 2FJG 2FJH 2QR0 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS More...
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