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Target Report Card

Target Name and Classification

Target ID CHEMBL1781868
Target Type SINGLE PROTEIN
Preferred Name Programmed cell death protein 4
Synonyms H731 | Neoplastic transformation inhibitor protein | Nuclear antigen H731-like | PDCD4 | Programmed cell death protein 4 | Protein 197/15a
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Programmed cell death protein 4 SINGLE PROTEIN Q53EL6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000150593
Ensembl ENSG00000150593
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0003723 (RNA binding)
GO:0005515 (protein binding)
GO Biological Process GO:0006915 (apoptotic process)
GO:0007569 (cell aging)
GO:0030509 (BMP signaling pathway)
GO:0034393 (positive regulation of smooth muscle cell apoptotic process)
GO:0035722 (interleukin-12-mediated signaling pathway)
GO:0043066 (negative regulation of apoptotic process)
GO:0043508 (negative regulation of JUN kinase activity)
GO:0045786 (negative regulation of cell cycle)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0050729 (positive regulation of inflammatory response)
GO:0051246 (regulation of protein metabolic process)
GO:0060940 (epithelial to mesenchymal transition involved in cardiac fibroblast development)
GO:0071222 (cellular response to lipopolysaccharide)
GO:1900016 (negative regulation of cytokine production involved in inflammatory response)
GO:1901224 (positive regulation of NIK/NF-kappaB signaling)
GO:1904706 (negative regulation of vascular smooth muscle cell proliferation)
GO:1904761 (negative regulation of myofibroblast differentiation)
GO:1905064 (negative regulation of vascular smooth muscle cell differentiation)
GO:1905461 (positive regulation of vascular associated smooth muscle cell apoptotic process)
GO:2000353 (positive regulation of endothelial cell apoptotic process)
Wikipedia PDCD4

Target Cross References - Protein

Human Protein Atlas ENSG00000150593
IntAct Q53EL6
Open Targets ENSG00000150593
PharmGKB PA33113
Reactome R-HSA-8950505 (Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.)
UniProt B2RCV4 B5ME91 O15501 Q53EL6 Q5VZS6 Q6PJI5 Q8TAR5 Q99834

Target Cross References - Domain

InterPro IPR003891 (Initiation_fac_eIF4g_MI.)
IPR016021 (MIF4-like_sf.)
IPR016024 (ARM-type_fold.)
Pfam PF02847 (MA3)

Target Cross References - Structure

PDBe 2RG8 2ZU6 3EIJ
CREDO 2RG8 2ZU6 3EIJ
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