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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1772932
Target Type SINGLE PROTEIN
Preferred Name Mitotic checkpoint serine/threonine-protein kinase BUB1
Synonyms BUB1 | BUB1A | BUB1L | Mitotic checkpoint serine/threonine-protein kinase BUB1 | hBUB1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Mitotic checkpoint serine/threonine-protein kinase BUB1 SINGLE PROTEIN O43683

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000169679
Ensembl ENSG00000169679
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000777 (condensed chromosome kinetochore)
GO:0000942 (condensed nuclear chromosome outer kinetochore)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005694 (chromosome)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007062 (sister chromatid cohesion)
GO:0007063 (regulation of sister chromatid cohesion)
GO:0007093 (mitotic cell cycle checkpoint)
GO:0007094 (mitotic spindle assembly checkpoint)
GO:0008283 (cell proliferation)
GO:0016032 (viral process)
GO:0016310 (phosphorylation)
GO:0051301 (cell division)
GO:0051754 (meiotic sister chromatid cohesion, centromeric)
GO:0051983 (regulation of chromosome segregation)
Wikipedia BUB1

Target Cross References - Protein

Human Protein Atlas ENSG00000169679
IntAct O43683
Guide to Pharmacology 1949
Open Targets ENSG00000169679
PharmGKB PA81
Pharos O43683 (Tchem)
Reactome R-HSA-141444 (Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-68877 (Mitotic Prometaphase.)
UniProt E9PC26 F5GXI5 O43430 O43643 O43683 O60626 Q53QE4

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR013212 (Mad3/Bub1_I.)
IPR015661 (Bub1/Mad3.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF08311 (Mad3_BUB1_I)

Target Cross References - Structure

PDBe 4A1G 4QPM 4R8Q 5DMZ
CREDO 4A1G 4QPM 4R8Q 5DMZ
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